| SP | Koufax, S.Koufax, Sandy $$ >> | 30 | 1965 | L | 97 | 28 | 28 | 11 | 11 | 4.71 | .314 | 1.35 | 8.7 | 3.5 | 7.6 | 185.1 | 179 | 101 | 97 | 24 | 72 | 157 | 0 | 0 | 0 | 0 | 13 | 4 | 4 | 4.22 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 27 | 26 | 10 | 10 | 3.99 | .289 | 1.20 | 8.2 | 2.6 | 8.4 | 178.0 | 163 | 83 | 79 | 28 | 51 | 167 | 2 | 0 | 0 | 1 | 14 | 3 | 3 | 4.08 |
| SP | Mathewson, C.Mathewson, Christy $$ >> | 28 | 1908 | R | 83 | 27 | 27 | 13 | 12 | 4.49 | .300 | 1.28 | 9.2 | 2.3 | 3.8 | 182.1 | 186 | 94 | 91 | 21 | 47 | 77 | 3 | 0 | 0 | 1 | 14 | 1 | 6 | 4.45 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 27 | 27 | 11 | 12 | 4.70 | .317 | 1.37 | 9.0 | 3.5 | 5.1 | 185.2 | 184 | 106 | 97 | 26 | 71 | 105 | 5 | 0 | 0 | 1 | 13 | 4 | 3 | 4.91 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 50 | 0 | 1 | 0 | 0.89 | .224 | 0.87 | 4.9 | 3.1 | 9.2 | 50.2 | 27 | 5 | 5 | 0 | 17 | 51 | 0 | 37 | 3 | 0 | 0 | 0 | 0 | 1.98 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 63 | 0 | 3 | 4 | 3.68 | .272 | 1.10 | 6.9 | 3.0 | 8.5 | 78.1 | 60 | 37 | 32 | 8 | 26 | 74 | 0 | 1 | 3 | 0 | 0 | 2 | 2 | 3.51 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 50 | 0 | 1 | 4 | 5.08 | .320 | 1.38 | 10.1 | 2.4 | 7.1 | 56.2 | 63 | 40 | 32 | 8 | 15 | 44 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.20 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 40 | 0 | 5 | 2 | 4.37 | .300 | 1.25 | 6.9 | 4.4 | 8.8 | 47.1 | 36 | 23 | 23 | 9 | 23 | 46 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 5.13 |