| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 14 | 14 | 6 | 5 | 3.65 | .285 | 1.20 | 7.3 | 3.6 | 9.8 | 88.2 | 71 | 41 | 36 | 11 | 35 | 96 | 0 | 0 | 0 | 0 | 10 | 0 | 0 | 3.64 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 13 | 13 | 6 | 4 | 5.25 | .323 | 1.39 | 9.4 | 3.1 | 8.5 | 72.0 | 75 | 44 | 42 | 10 | 25 | 68 | 0 | 0 | 0 | 0 | 6 | 3 | 2 | 4.08 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 13 | 13 | 9 | 2 | 2.99 | .275 | 1.11 | 7.5 | 2.5 | 9.8 | 90.1 | 75 | 33 | 30 | 6 | 25 | 98 | 2 | 0 | 0 | 2 | 8 | 3 | 0 | 2.62 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 12 | 12 | 6 | 3 | 5.43 | .333 | 1.50 | 10.0 | 3.7 | 7.3 | 64.2 | 71 | 40 | 39 | 5 | 26 | 52 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 3.61 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 26 | 0 | 0 | 2 | 1.30 | .239 | 0.94 | 5.3 | 3.3 | 9.3 | 27.2 | 16 | 4 | 4 | 3 | 10 | 28 | 0 | 14 | 0 | 0 | 0 | 0 | 0 | 3.48 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 29 | 0 | 0 | 1 | 2.06 | .245 | 0.97 | 5.9 | 2.8 | 7.2 | 35.0 | 23 | 13 | 8 | 0 | 11 | 28 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 2.34 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 27 | 0 | 2 | 1 | 4.34 | .310 | 1.34 | 9.0 | 3.1 | 13.0 | 29.0 | 29 | 16 | 14 | 5 | 10 | 42 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.38 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 37 | 0 | 1 | 1 | 2.70 | .301 | 1.29 | 8.2 | 3.5 | 8.5 | 33.1 | 30 | 10 | 10 | 3 | 13 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.48 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 21 | 0 | 3 | 0 | 4.39 | .298 | 1.24 | 6.9 | 4.5 | 14.2 | 26.2 | 20 | 13 | 13 | 1 | 13 | 41 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 1.96 |