| SP | Sale, C.Sale, Chris † $ >> | 29 | 2018 | L | 98 | 34 | 34 | 20 | 8 | 3.54 | .273 | 1.08 | 7.5 | 2.3 | 8.4 | 198.1 | 164 | 83 | 78 | 20 | 51 | 184 | 1 | 0 | 0 | 1 | 18 | 8 | 6 | 3.35 |
| SP | Maddux, G.Maddux, Greg † $ >> | 29 | 1995 | R | 89 | 33 | 33 | 18 | 11 | 3.02 | .260 | 1.04 | 7.6 | 1.7 | 5.6 | 244.0 | 207 | 87 | 82 | 26 | 46 | 151 | 11 | 0 | 0 | 1 | 24 | 4 | 2 | 3.76 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 32 | 32 | 15 | 9 | 3.19 | .293 | 1.23 | 7.2 | 3.9 | 6.8 | 205.2 | 164 | 76 | 73 | 19 | 89 | 156 | 2 | 0 | 0 | 1 | 23 | 3 | 5 | 4.03 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 29 | 29 | 16 | 8 | 4.02 | .313 | 1.35 | 8.7 | 3.5 | 3.8 | 183.2 | 177 | 90 | 82 | 17 | 71 | 78 | 5 | 0 | 0 | 1 | 15 | 3 | 6 | 4.57 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 95 | 0 | 3 | 2 | 2.52 | .265 | 1.06 | 5.0 | 4.6 | 9.3 | 103.2 | 57 | 34 | 29 | 6 | 53 | 107 | 0 | 5 | 5 | 0 | 0 | 2 | 3 | 3.28 |
| RP | Saito, T.Saito, Takashi † >> | 37 | 2007 | R | 91 | 82 | 0 | 5 | 3 | 2.17 | .250 | 0.98 | 5.9 | 3.0 | 7.2 | 112.0 | 73 | 29 | 27 | 12 | 37 | 89 | 0 | 13 | 3 | 0 | 0 | 2 | 0 | 3.85 |
| RP | Soriano, R.Soriano, Rafael # >> | 24 | 2003 | R | 84 | 76 | 0 | 5 | 4 | 4.68 | .299 | 1.23 | 7.4 | 3.8 | 7.4 | 67.1 | 55 | 40 | 35 | 8 | 28 | 55 | 0 | 14 | 3 | 0 | 0 | 3 | 0 | 4.30 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 50 | 0 | 3 | 1 | 2.25 | .276 | 1.13 | 7.2 | 2.9 | 6.9 | 56.0 | 45 | 14 | 14 | 4 | 18 | 43 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 3.41 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 35 | 0 | 5 | 1 | 5.09 | .315 | 1.38 | 7.0 | 5.6 | 8.3 | 40.2 | 31 | 23 | 23 | 4 | 25 | 37 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 4.33 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 34 | 0 | 3 | 0 | 2.82 | .286 | 1.20 | 8.1 | 2.8 | 9.2 | 38.1 | 34 | 14 | 12 | 3 | 12 | 39 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 2.92 |