| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 29 | 29 | 12 | 9 | 5.38 | .317 | 1.39 | 10.1 | 2.4 | 7.8 | 155.2 | 174 | 93 | 93 | 29 | 42 | 135 | 0 | 0 | 0 | 0 | 14 | 1 | 1 | 4.52 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 28 | 28 | 14 | 5 | 3.32 | .270 | 1.10 | 7.7 | 2.2 | 8.0 | 187.0 | 160 | 72 | 69 | 32 | 45 | 166 | 5 | 0 | 0 | 3 | 17 | 3 | 1 | 4.22 |
| SP | Fernandez, S.Fernandez, Sid † >> | 23 | 1985 | L | 49 | 29 | 27 | 16 | 5 | 3.34 | .284 | 1.19 | 6.1 | 4.6 | 7.2 | 180.1 | 122 | 72 | 67 | 21 | 92 | 143 | 3 | 1 | 0 | 1 | 17 | 1 | 3 | 4.48 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 27 | 27 | 12 | 8 | 4.04 | .280 | 1.15 | 7.8 | 2.5 | 6.0 | 187.0 | 163 | 86 | 84 | 25 | 52 | 124 | 12 | 0 | 0 | 0 | 13 | 3 | 4 | 4.29 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 6 | 6 | 1 | 3 | 4.35 | .322 | 1.42 | 7.8 | 5.1 | 3.5 | 39.1 | 34 | 27 | 19 | 4 | 22 | 15 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 5.26 |
| RP | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 77 | 0 | 13 | 2 | 1.77 | .240 | 0.92 | 5.3 | 2.9 | 8.3 | 86.1 | 51 | 20 | 17 | 6 | 28 | 79 | 0 | 0 | 2 | 0 | 0 | 3 | 7 | 3.15 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 54 | 0 | 3 | 1 | 3.53 | .271 | 1.07 | 6.4 | 3.3 | 8.1 | 63.2 | 45 | 26 | 25 | 3 | 23 | 57 | 0 | 5 | 1 | 0 | 0 | 3 | 5 | 3.05 |
| RP | Betancourt, R.Betancourt, Rafael # >> | 32 | 2007 | R | 77 | 47 | 0 | 2 | 4 | 5.33 | .332 | 1.43 | 10.2 | 2.8 | 8.0 | 52.1 | 59 | 32 | 31 | 11 | 16 | 46 | 0 | 7 | 2 | 0 | 0 | 3 | 0 | 5.08 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 29 | 0 | 1 | 1 | 3.41 | .331 | 1.45 | 6.2 | 6.8 | 8.4 | 29.0 | 20 | 11 | 11 | 2 | 22 | 27 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 4.41 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 36 | 0 | 4 | 2 | 3.12 | .248 | 0.97 | 5.8 | 3.0 | 5.4 | 57.2 | 37 | 22 | 20 | 5 | 19 | 34 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 4.00 |