| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 33 | 33 | 21 | 6 | 3.24 | .276 | 1.13 | 8.0 | 2.2 | 6.8 | 225.1 | 200 | 82 | 81 | 26 | 54 | 171 | 0 | 0 | 0 | 0 | 23 | 4 | 0 | 3.76 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 33 | 33 | 9 | 16 | 4.19 | .310 | 1.35 | 9.7 | 2.5 | 5.6 | 229.2 | 246 | 108 | 107 | 27 | 63 | 143 | 6 | 0 | 0 | 2 | 19 | 1 | 4 | 4.12 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 79 | 32 | 32 | 11 | 11 | 6.01 | .325 | 1.42 | 10.0 | 2.8 | 8.2 | 184.1 | 204 | 130 | 123 | 31 | 58 | 167 | 0 | 0 | 0 | 0 | 15 | 4 | 11 | 4.39 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 31 | 31 | 14 | 9 | 5.62 | .330 | 1.47 | 11.4 | 1.9 | 5.1 | 209.2 | 264 | 134 | 131 | 32 | 45 | 118 | 8 | 0 | 0 | 0 | 10 | 1 | 1 | 4.52 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 87 | 0 | 9 | 1 | 2.93 | .294 | 1.23 | 6.5 | 4.7 | 8.0 | 113.2 | 81 | 41 | 37 | 8 | 59 | 100 | 0 | 11 | 0 | 0 | 0 | 2 | 2 | 3.77 |
| RP | Miller, A.Miller, Andrew † >> | 31 | 2016 | L | 91 | 76 | 0 | 6 | 1 | 1.32 | .209 | 0.76 | 5.4 | 1.5 | 8.3 | 95.2 | 57 | 16 | 14 | 8 | 16 | 88 | 0 | 17 | 2 | 0 | 0 | 3 | 2 | 2.84 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 50 | 0 | 5 | 4 | 5.04 | .308 | 1.30 | 9.5 | 2.3 | 8.7 | 55.1 | 58 | 31 | 31 | 13 | 14 | 53 | 0 | 5 | 1 | 0 | 0 | 2 | 0 | 5.02 |
| RP | Benitez, A.Benitez, Armando # >> | 32 | 2004 | R | 81 | 44 | 0 | 5 | 2 | 5.17 | .312 | 1.34 | 8.8 | 3.3 | 5.0 | 47.0 | 46 | 27 | 27 | 6 | 17 | 26 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 4.70 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 34 | 0 | 3 | 1 | 2.51 | .278 | 1.09 | 7.4 | 2.5 | 8.0 | 46.2 | 38 | 15 | 13 | 3 | 13 | 41 | 0 | 4 | 0 | 0 | 0 | 3 | 1 | 3.11 |