| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 32 | 32 | 12 | 14 | 4.00 | .294 | 1.24 | 8.4 | 2.8 | 8.5 | 234.0 | 218 | 109 | 104 | 37 | 72 | 222 | 11 | 0 | 0 | 3 | 20 | 3 | 4 | 4.12 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 65 | 31 | 31 | 13 | 13 | 4.82 | .313 | 1.33 | 8.7 | 3.2 | 4.2 | 194.1 | 188 | 116 | 104 | 25 | 70 | 91 | 1 | 0 | 0 | 0 | 14 | 7 | 3 | 4.93 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 26 | 2016 | R | 56 | 32 | 31 | 4 | 19 | 6.45 | .331 | 1.45 | 10.8 | 2.3 | 5.7 | 171.2 | 205 | 130 | 123 | 29 | 44 | 109 | 0 | 0 | 0 | 0 | 10 | 6 | 5 | 4.81 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 47 | 30 | 29 | 9 | 12 | 5.82 | .319 | 1.40 | 10.3 | 2.3 | 5.0 | 190.1 | 218 | 128 | 123 | 31 | 48 | 106 | 7 | 0 | 0 | 1 | 12 | 2 | 3 | 4.79 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 95 | 0 | 5 | 4 | 4.84 | .345 | 1.53 | 8.5 | 5.3 | 9.6 | 115.1 | 108 | 67 | 62 | 14 | 68 | 123 | 0 | 6 | 3 | 0 | 0 | 6 | 3 | 4.37 |
| RP | Treinen, B.Treinen, Blake # >> | 30 | 2018 | R | 79 | 75 | 0 | 3 | 5 | 5.06 | .322 | 1.42 | 9.2 | 3.6 | 8.3 | 96.0 | 98 | 59 | 54 | 13 | 38 | 89 | 0 | 8 | 2 | 0 | 0 | 1 | 3 | 4.13 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 63 | 0 | 1 | 5 | 4.93 | .307 | 1.31 | 9.7 | 2.1 | 8.4 | 80.1 | 86 | 47 | 44 | 11 | 19 | 75 | 0 | 10 | 2 | 0 | 0 | 2 | 0 | 3.70 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 47 | 0 | 2 | 4 | 4.75 | .326 | 1.45 | 8.7 | 4.5 | 10.4 | 60.2 | 58 | 35 | 32 | 8 | 30 | 69 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 3.93 |