| SP | Tiant, L.Tiant, Luis † # >> | 28 | 1968 | R | 97 | 30 | 30 | 18 | 7 | 3.38 | .294 | 1.24 | 8.2 | 3.0 | 8.4 | 221.1 | 202 | 91 | 83 | 30 | 73 | 206 | 7 | 0 | 0 | 1 | 19 | 1 | 3 | 3.90 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 84 | 31 | 31 | 16 | 8 | 3.52 | .307 | 1.30 | 9.0 | 2.8 | 5.2 | 227.2 | 227 | 106 | 89 | 19 | 70 | 131 | 6 | 0 | 0 | 1 | 19 | 6 | 3 | 3.94 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 31 | 31 | 10 | 18 | 4.87 | .300 | 1.27 | 8.9 | 2.6 | 7.3 | 212.2 | 209 | 117 | 115 | 34 | 61 | 171 | 3 | 0 | 0 | 1 | 13 | 4 | 3 | 4.39 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 31 | 31 | 10 | 12 | 4.27 | .312 | 1.35 | 9.0 | 3.2 | 5.6 | 213.0 | 212 | 108 | 101 | 25 | 76 | 132 | 4 | 0 | 0 | 1 | 16 | 2 | 4 | 4.38 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 83 | 0 | 9 | 4 | 3.29 | .308 | 1.33 | 7.9 | 4.1 | 9.1 | 126.0 | 110 | 48 | 46 | 10 | 58 | 127 | 0 | 11 | 4 | 0 | 0 | 0 | 0 | 3.40 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 81 | 69 | 0 | 2 | 2 | 4.34 | .302 | 1.27 | 8.9 | 2.7 | 7.2 | 74.2 | 73 | 37 | 36 | 9 | 22 | 59 | 0 | 12 | 4 | 0 | 0 | 2 | 2 | 3.96 |
| RP | Bailey, A.Bailey, Andrew # >> | 25 | 2009 | R | 66 | 44 | 0 | 2 | 2 | 6.57 | .351 | 1.60 | 9.4 | 5.1 | 8.6 | 49.1 | 51 | 40 | 36 | 12 | 28 | 47 | 0 | 5 | 1 | 0 | 0 | 1 | 6 | 6.04 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 38 | 0 | 0 | 2 | 4.58 | .374 | 1.79 | 8.5 | 7.8 | 8.5 | 37.1 | 35 | 19 | 19 | 3 | 32 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.76 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 2 | 2 | 1 | 1 | 3.78 | .286 | 1.20 | 9.0 | 2.3 | 6.2 | 16.2 | 16 | 7 | 7 | 1 | 4 | 11 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 3.19 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 62 | 10 | 0 | 2 | 1 | 9.00 | .429 | 2.17 | 12.8 | 6.8 | 5.3 | 12.0 | 17 | 12 | 12 | 3 | 9 | 7 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 7.58 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 60 | 33 | 0 | 3 | 5 | 7.69 | .399 | 1.97 | 12.2 | 5.7 | 7.3 | 57.1 | 77 | 49 | 49 | 11 | 36 | 46 | 0 | 2 | 3 | 0 | 0 | 1 | 4 | 5.84 |