| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 35 | 35 | 11 | 12 | 5.13 | .306 | 1.29 | 8.6 | 3.1 | 8.9 | 203.1 | 193 | 119 | 116 | 30 | 70 | 201 | 1 | 0 | 0 | 1 | 18 | 6 | 5 | 4.06 |
| SP | Maddux, G.Maddux, Greg † # >> | 29 | 1995 | R | 89 | 34 | 34 | 22 | 9 | 4.03 | .293 | 1.21 | 8.9 | 2.1 | 5.8 | 248.0 | 244 | 124 | 111 | 36 | 57 | 159 | 7 | 0 | 0 | 0 | 17 | 8 | 7 | 4.39 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 32 | 32 | 14 | 11 | 4.83 | .308 | 1.31 | 8.9 | 2.9 | 4.6 | 234.2 | 232 | 129 | 126 | 19 | 75 | 119 | 9 | 0 | 0 | 0 | 10 | 6 | 9 | 4.08 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 77 | 0 | 12 | 3 | 2.95 | .266 | 1.04 | 5.7 | 3.7 | 7.9 | 106.2 | 67 | 37 | 35 | 8 | 44 | 93 | 0 | 1 | 4 | 0 | 0 | 5 | 0 | 3.61 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 42 | 0 | 3 | 3 | 4.30 | .313 | 1.34 | 8.0 | 4.1 | 8.2 | 44.0 | 39 | 21 | 21 | 8 | 20 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.98 |
| CL | Diaz, E.Diaz, Edwin † $$ >> | 24 | 2018 | R | 87 | 65 | 0 | 0 | 1 | 2.80 | .256 | 1.03 | 6.2 | 3.1 | 11.2 | 61.0 | 42 | 19 | 19 | 7 | 21 | 76 | 0 | 55 | 5 | 0 | 0 | 0 | 3 | 3.03 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 18 | 0 | 2 | 0 | 0.00 | .267 | 1.09 | 5.0 | 5.0 | 9.0 | 18.1 | 10 | 0 | 0 | 0 | 10 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 2.67 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 22 | 0 | 0 | 1 | 8.10 | .388 | 1.85 | 9.0 | 7.7 | 10.4 | 20.0 | 20 | 18 | 18 | 2 | 17 | 23 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 4.70 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 19 | 0 | 7 | 1 | 4.51 | .325 | 1.42 | 9.1 | 3.7 | 6.6 | 101.2 | 102 | 52 | 51 | 15 | 42 | 74 | 0 | 0 | 0 | 0 | 0 | 3 | 5 | 4.80 |