| SP | Verlander, J.Verlander, Justin $ >> | 36 | 2019 | R | 99 | 21 | 21 | 7 | 8 | 3.59 | .284 | 1.17 | 7.5 | 3.1 | 7.9 | 143.0 | 119 | 59 | 57 | 12 | 49 | 126 | 2 | 0 | 0 | 1 | 15 | 2 | 1 | 3.40 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 20 | 20 | 6 | 12 | 5.04 | .293 | 1.22 | 8.4 | 2.6 | 7.8 | 130.1 | 122 | 76 | 73 | 20 | 37 | 112 | 4 | 0 | 0 | 0 | 12 | 3 | 3 | 4.20 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 20 | 20 | 6 | 7 | 4.53 | .294 | 1.24 | 8.1 | 3.0 | 5.2 | 133.0 | 120 | 76 | 67 | 19 | 45 | 77 | 4 | 0 | 0 | 1 | 10 | 1 | 1 | 4.74 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 19 | 19 | 8 | 7 | 3.43 | .275 | 1.11 | 7.7 | 2.3 | 5.1 | 141.2 | 121 | 58 | 54 | 15 | 36 | 80 | 4 | 0 | 0 | 3 | 12 | 4 | 0 | 4.10 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 39 | 0 | 4 | 2 | 2.79 | .266 | 1.06 | 7.8 | 1.9 | 6.6 | 38.2 | 33 | 12 | 12 | 6 | 8 | 28 | 0 | 23 | 2 | 0 | 0 | 1 | 0 | 4.29 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 45 | 0 | 4 | 2 | 5.33 | .338 | 1.53 | 9.9 | 3.9 | 7.0 | 49.0 | 54 | 30 | 29 | 8 | 21 | 38 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 4.86 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 26 | 0 | 2 | 1 | 3.00 | .250 | 0.97 | 6.0 | 2.7 | 8.7 | 30.0 | 20 | 11 | 10 | 2 | 9 | 29 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2.93 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 1 | 0 | 0 | 0 | 0.00 | .154 | 0.55 | 6.0 | 0.0 | 12.0 | 3.2 | 2 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.33 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 6 | 0 | 2 | 1 | 1.23 | .267 | 1.09 | 6.4 | 3.9 | 5.1 | 7.1 | 5 | 1 | 1 | 0 | 3 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.14 |