| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 32 | 32 | 10 | 8 | 4.01 | .290 | 1.20 | 8.5 | 2.3 | 9.3 | 211.0 | 199 | 103 | 94 | 28 | 54 | 218 | 4 | 0 | 0 | 1 | 16 | 6 | 3 | 3.51 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 74 | 33 | 31 | 17 | 7 | 3.58 | .307 | 1.31 | 8.6 | 3.2 | 6.3 | 203.2 | 194 | 86 | 81 | 26 | 73 | 142 | 2 | 0 | 0 | 1 | 21 | 4 | 3 | 4.40 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 76 | 0 | 7 | 8 | 4.18 | .266 | 1.06 | 6.9 | 2.6 | 8.6 | 92.2 | 71 | 45 | 43 | 14 | 27 | 88 | 0 | 32 | 3 | 0 | 0 | 3 | 1 | 4.04 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 84 | 0 | 3 | 4 | 3.95 | .329 | 1.46 | 8.5 | 4.6 | 10.0 | 93.1 | 88 | 54 | 41 | 13 | 48 | 103 | 0 | 2 | 4 | 0 | 0 | 1 | 0 | 4.18 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 86 | 83 | 0 | 4 | 5 | 3.82 | .274 | 1.12 | 6.9 | 3.2 | 11.0 | 99.0 | 76 | 44 | 42 | 16 | 35 | 121 | 0 | 3 | 4 | 0 | 0 | 1 | 4 | 3.75 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 73 | 0 | 3 | 3 | 3.66 | .304 | 1.30 | 6.8 | 5.0 | 8.5 | 78.2 | 59 | 37 | 32 | 9 | 43 | 74 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 4.29 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 62 | 0 | 9 | 1 | 4.08 | .298 | 1.25 | 9.2 | 2.1 | 9.1 | 81.2 | 83 | 38 | 37 | 11 | 19 | 82 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 3.52 |