| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 19 | 19 | 8 | 10 | 4.87 | .313 | 1.32 | 9.2 | 2.7 | 9.8 | 109.0 | 111 | 62 | 59 | 19 | 33 | 119 | 2 | 0 | 0 | 0 | 11 | 5 | 2 | 4.13 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 19 | 19 | 6 | 6 | 4.70 | .309 | 1.33 | 8.6 | 3.4 | 10.2 | 107.1 | 102 | 56 | 56 | 8 | 41 | 121 | 0 | 0 | 0 | 0 | 11 | 1 | 3 | 2.89 |
| SP | Cameron, N.Cameron, Noah >> | 25 | 2025 | L | 81 | 17 | 17 | 6 | 6 | 7.34 | .398 | 1.96 | 12.5 | 5.2 | 6.6 | 79.2 | 110 | 73 | 65 | 5 | 46 | 58 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.18 |
| SP | Springs, J.Springs, Jeffrey >> | 32 | 2025 | L | 67 | 19 | 16 | 2 | 7 | 6.61 | .367 | 1.71 | 11.5 | 3.9 | 7.5 | 80.1 | 102 | 59 | 59 | 19 | 35 | 67 | 0 | 1 | 0 | 0 | 5 | 3 | 0 | 5.84 |
| CL | Miller, M.Miller, Mason † >> | 26 | 2025 | R | 98 | 46 | 0 | 1 | 3 | 3.19 | .301 | 1.23 | 7.5 | 3.6 | 12.9 | 48.0 | 40 | 18 | 17 | 4 | 19 | 69 | 0 | 19 | 2 | 0 | 0 | 3 | 1 | 2.58 |
| SU | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 92 | 48 | 0 | 2 | 1 | 4.05 | .344 | 1.54 | 10.7 | 3.2 | 8.3 | 53.1 | 63 | 24 | 24 | 10 | 19 | 49 | 0 | 0 | 3 | 0 | 0 | 2 | 0 | 4.79 |
| RP | Weaver, L.Weaver, Luke >> | 31 | 2025 | R | 83 | 51 | 0 | 5 | 1 | 4.48 | .323 | 1.43 | 9.3 | 3.7 | 10.7 | 64.1 | 66 | 35 | 32 | 10 | 26 | 76 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 3.88 |
| RP | Iglesias, R.Iglesias, Raisel † >> | 35 | 2025 | R | 78 | 49 | 0 | 5 | 2 | 2.97 | .278 | 1.12 | 7.5 | 2.7 | 11.7 | 60.2 | 50 | 21 | 20 | 8 | 18 | 78 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 3.13 |
| RP | O'Brien, R.O'Brien, Riley >> | 30 | 2025 | R | 69 | 44 | 0 | 2 | 2 | 6.26 | .370 | 1.74 | 10.6 | 5.1 | 8.8 | 46.0 | 54 | 33 | 32 | 10 | 26 | 45 | 0 | 2 | 3 | 0 | 0 | 1 | 1 | 5.63 |
| RP | Santana, D.Santana, Dennis >> | 29 | 2025 | R | 92 | 37 | 0 | 1 | 2 | 2.12 | .263 | 1.01 | 6.8 | 2.3 | 6.8 | 46.2 | 35 | 11 | 11 | 3 | 12 | 35 | 0 | 3 | 2 | 0 | 0 | 3 | 0 | 3.30 |