| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 100 | 35 | 35 | 15 | 8 | 2.99 | .261 | 1.05 | 7.4 | 2.0 | 10.8 | 241.0 | 199 | 85 | 80 | 21 | 53 | 289 | 2 | 0 | 0 | 0 | 26 | 3 | 3 | 2.43 |
| SP | Crochet, G.Crochet, Garrett >> | 26 | 2025 | L | 89 | 32 | 32 | 11 | 9 | 4.28 | .306 | 1.30 | 9.2 | 2.5 | 10.3 | 195.2 | 200 | 93 | 93 | 29 | 54 | 224 | 3 | 0 | 0 | 2 | 18 | 5 | 5 | 3.54 |
| SP | Horton, C.Horton, Cade # >> | 23 | 2025 | R | 79 | 32 | 32 | 7 | 14 | 4.90 | .334 | 1.48 | 9.7 | 3.6 | 7.0 | 167.0 | 180 | 97 | 91 | 20 | 67 | 129 | 0 | 0 | 0 | 0 | 9 | 4 | 3 | 4.29 |
| SP | Kelly, M.Kelly, Merrill >> | 36 | 2025 | R | 73 | 31 | 31 | 14 | 10 | 5.28 | .338 | 1.49 | 10.2 | 3.2 | 7.6 | 174.0 | 197 | 102 | 102 | 29 | 62 | 146 | 0 | 0 | 0 | 0 | 10 | 7 | 2 | 4.68 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 88 | 80 | 0 | 7 | 6 | 3.73 | .293 | 1.21 | 7.2 | 3.7 | 7.8 | 101.1 | 81 | 45 | 42 | 10 | 42 | 87 | 0 | 6 | 6 | 0 | 0 | 3 | 5 | 3.90 |
| RP | Strahm, M.Strahm, Matt >> | 33 | 2025 | L | 72 | 55 | 0 | 5 | 1 | 3.27 | .300 | 1.27 | 7.6 | 3.8 | 11.2 | 66.0 | 56 | 25 | 24 | 10 | 28 | 82 | 0 | 9 | 3 | 0 | 0 | 1 | 1 | 3.80 |
| RP | Weaver, L.Weaver, Luke >> | 31 | 2025 | R | 83 | 47 | 0 | 2 | 4 | 4.75 | .323 | 1.40 | 9.2 | 3.4 | 10.4 | 53.0 | 54 | 28 | 28 | 9 | 20 | 61 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 4.15 |
| SP | Taillon, J.Taillon, Jameson >> | 33 | 2025 | R | 77 | 27 | 0 | 6 | 1 | 5.76 | .357 | 1.65 | 10.6 | 4.3 | 8.2 | 104.2 | 123 | 69 | 67 | 19 | 50 | 95 | 0 | 1 | 1 | 0 | 0 | 1 | 5 | 5.02 |