| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 38 | 38 | 19 | 11 | 2.88 | .262 | 1.04 | 6.8 | 2.6 | 6.9 | 284.2 | 213 | 102 | 91 | 32 | 82 | 219 | 7 | 0 | 0 | 3 | 27 | 8 | 4 | 3.87 |
| SP | Snell, B.Snell, Blake # $$ >> | 25 | 2018 | L | 88 | 37 | 37 | 15 | 10 | 4.18 | .291 | 1.20 | 7.2 | 3.6 | 9.4 | 223.2 | 179 | 111 | 104 | 30 | 89 | 234 | 0 | 0 | 0 | 0 | 22 | 7 | 17 | 3.94 |
| SP | Johnson, R.Johnson, Randy † $$ >> | 41 | 2004 | L | 89 | 35 | 35 | 23 | 3 | 2.78 | .255 | 1.00 | 6.7 | 2.3 | 9.0 | 265.0 | 196 | 89 | 82 | 26 | 69 | 264 | 11 | 0 | 0 | 4 | 24 | 7 | 7 | 3.14 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 81 | 34 | 34 | 15 | 9 | 3.78 | .281 | 1.15 | 7.6 | 2.8 | 6.5 | 245.1 | 207 | 103 | 103 | 30 | 75 | 177 | 13 | 0 | 0 | 5 | 18 | 5 | 9 | 4.13 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 72 | 33 | 31 | 17 | 10 | 4.05 | .293 | 1.23 | 7.8 | 3.3 | 6.6 | 224.1 | 194 | 103 | 101 | 38 | 81 | 164 | 11 | 0 | 0 | 3 | 16 | 4 | 6 | 4.88 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 87 | 0 | 9 | 5 | 3.40 | .279 | 1.14 | 7.2 | 3.1 | 9.7 | 113.2 | 91 | 44 | 43 | 14 | 39 | 122 | 0 | 8 | 5 | 0 | 0 | 2 | 7 | 3.54 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 78 | 0 | 3 | 4 | 2.10 | .264 | 1.07 | 5.5 | 4.1 | 9.4 | 90.0 | 55 | 21 | 21 | 8 | 41 | 94 | 0 | 12 | 4 | 0 | 0 | 1 | 8 | 3.47 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 83 | 49 | 0 | 4 | 6 | 4.88 | .323 | 1.43 | 9.4 | 3.7 | 11.6 | 51.2 | 53 | 30 | 28 | 8 | 21 | 66 | 0 | 9 | 3 | 0 | 0 | 0 | 3 | 3.69 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 77 | 25 | 0 | 2 | 2 | 2.67 | .222 | 0.86 | 6.3 | 1.5 | 5.4 | 30.1 | 21 | 9 | 9 | 4 | 5 | 18 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 4.03 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 27 | 0 | 0 | 2 | 3.30 | .280 | 1.17 | 5.7 | 4.8 | 11.1 | 30.0 | 19 | 11 | 11 | 4 | 16 | 37 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 3.87 |