| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 95 | 17 | 17 | 7 | 6 | 4.62 | .293 | 1.21 | 8.3 | 2.7 | 7.9 | 101.1 | 93 | 53 | 52 | 17 | 30 | 89 | 4 | 0 | 0 | 3 | 7 | 3 | 2 | 4.41 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 88 | 16 | 16 | 7 | 3 | 4.37 | .280 | 1.15 | 7.4 | 3.1 | 6.1 | 82.1 | 67 | 42 | 40 | 15 | 28 | 56 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 5.07 |
| SP | Strider, S.Strider, Spencer >> | 23 | 2022 | R | 80 | 17 | 15 | 2 | 6 | 6.03 | .348 | 1.57 | 10.1 | 4.2 | 8.0 | 65.2 | 73 | 44 | 44 | 12 | 30 | 58 | 0 | 1 | 0 | 0 | 2 | 2 | 4 | 5.09 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 43 | 0 | 8 | 0 | 1.33 | .235 | 0.88 | 4.5 | 3.5 | 9.3 | 54.1 | 27 | 10 | 8 | 2 | 21 | 56 | 0 | 1 | 2 | 0 | 0 | 2 | 2 | 2.69 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 78 | 35 | 0 | 1 | 1 | 3.53 | .312 | 1.32 | 8.6 | 3.3 | 11.1 | 43.1 | 41 | 18 | 17 | 4 | 16 | 53 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 3.00 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 77 | 33 | 0 | 7 | 1 | 3.04 | .241 | 0.93 | 6.7 | 1.8 | 9.7 | 50.1 | 37 | 20 | 17 | 5 | 10 | 54 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 2.80 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 76 | 30 | 0 | 3 | 1 | 5.85 | .358 | 1.67 | 10.7 | 4.5 | 5.6 | 32.1 | 38 | 22 | 21 | 4 | 16 | 20 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 4.88 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 69 | 19 | 0 | 1 | 0 | 0.71 | .216 | 0.83 | 4.0 | 3.6 | 10.8 | 25.1 | 11 | 2 | 2 | 1 | 10 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.32 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 67 | 14 | 0 | 1 | 1 | 3.95 | .281 | 1.17 | 6.2 | 4.8 | 6.9 | 13.2 | 9 | 6 | 6 | 4 | 7 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.08 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 13 | 0 | 0 | 0 | 2.63 | .281 | 1.17 | 6.2 | 4.8 | 9.7 | 13.2 | 9 | 4 | 4 | 0 | 7 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.46 |