| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 73 | 32 | 32 | 11 | 16 | 4.80 | .319 | 1.37 | 9.2 | 3.2 | 5.4 | 243.2 | 248 | 136 | 130 | 31 | 87 | 146 | 15 | 0 | 0 | 3 | 12 | 8 | 7 | 4.63 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 32 | 32 | 11 | 12 | 4.39 | .305 | 1.30 | 8.3 | 3.4 | 5.7 | 244.0 | 225 | 128 | 119 | 31 | 92 | 154 | 10 | 0 | 0 | 2 | 15 | 4 | 9 | 4.57 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 30 | 30 | 9 | 15 | 5.02 | .326 | 1.44 | 10.1 | 2.8 | 4.5 | 209.2 | 235 | 121 | 117 | 31 | 66 | 105 | 8 | 0 | 0 | 2 | 14 | 3 | 10 | 4.91 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 77 | 0 | 7 | 5 | 3.51 | .316 | 1.36 | 7.3 | 5.0 | 7.2 | 102.2 | 83 | 47 | 40 | 6 | 57 | 82 | 0 | 7 | 2 | 0 | 0 | 2 | 1 | 3.89 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 70 | 0 | 5 | 4 | 3.93 | .276 | 1.15 | 7.6 | 2.8 | 8.5 | 91.2 | 77 | 42 | 40 | 17 | 28 | 86 | 0 | 7 | 3 | 0 | 0 | 0 | 0 | 4.46 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 46 | 0 | 3 | 3 | 2.65 | .294 | 1.25 | 6.2 | 5.2 | 7.2 | 54.1 | 37 | 24 | 16 | 8 | 31 | 43 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 5.06 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 56 | 32 | 0 | 2 | 3 | 4.64 | .308 | 1.30 | 7.1 | 4.6 | 6.5 | 33.0 | 26 | 17 | 17 | 4 | 17 | 24 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 4.76 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 12 | 1 | 0 | 2 | 6.10 | .367 | 1.69 | 12.6 | 3.2 | 5.0 | 20.2 | 28 | 15 | 14 | 4 | 7 | 11 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 5.70 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 1 | 0 | 0 | 0 | 20.25 | .429 | 2.25 | 18.0 | 9.0 | 9.0 | 1.1 | 2 | 3 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 17.00 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 6 | 0 | 1 | 1 | 11.81 | .484 | 2.81 | 19.8 | 7.2 | 3.6 | 5.1 | 11 | 7 | 7 | 1 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 7.20 |