| SP | deGrom, J.deGrom, Jacob † $ >> | 33 | 2021 | R | 100 | 34 | 34 | 18 | 5 | 2.61 | .243 | 0.95 | 6.9 | 1.7 | 8.3 | 241.0 | 184 | 73 | 70 | 15 | 45 | 222 | 2 | 0 | 0 | 1 | 27 | 3 | 0 | 2.56 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 33 | 33 | 21 | 7 | 2.87 | .272 | 1.10 | 6.3 | 3.6 | 3.2 | 247.2 | 172 | 81 | 79 | 17 | 100 | 89 | 7 | 0 | 0 | 3 | 26 | 5 | 4 | 4.45 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 33 | 33 | 13 | 11 | 4.54 | .332 | 1.47 | 7.8 | 5.5 | 8.8 | 168.1 | 146 | 91 | 85 | 15 | 102 | 165 | 0 | 0 | 0 | 0 | 14 | 3 | 14 | 4.07 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 31 | 31 | 15 | 5 | 3.55 | .307 | 1.32 | 7.4 | 4.5 | 7.6 | 167.1 | 137 | 69 | 66 | 19 | 84 | 141 | 1 | 0 | 0 | 0 | 18 | 1 | 2 | 4.32 |
| RP | Miller, A.Miller, Andrew † >> | 32 | 2017 | L | 86 | 90 | 0 | 8 | 2 | 1.73 | .227 | 0.88 | 4.6 | 3.4 | 8.6 | 83.0 | 42 | 16 | 16 | 5 | 31 | 79 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 79 | 0 | 2 | 2 | 2.87 | .292 | 1.22 | 6.1 | 5.0 | 10.1 | 59.2 | 40 | 19 | 19 | 2 | 33 | 66 | 0 | 8 | 1 | 0 | 0 | 1 | 5 | 2.93 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 35 | 75 | 0 | 1 | 1 | 3.99 | .296 | 1.26 | 7.3 | 4.2 | 7.9 | 58.2 | 47 | 27 | 26 | 7 | 27 | 51 | 0 | 6 | 1 | 0 | 0 | 0 | 2 | 4.21 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 57 | 58 | 0 | 4 | 5 | 4.47 | .276 | 1.13 | 6.4 | 3.8 | 8.7 | 52.1 | 37 | 27 | 26 | 8 | 22 | 50 | 0 | 7 | 4 | 0 | 0 | 1 | 1 | 4.40 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 32 | 67 | 0 | 7 | 2 | 1.66 | .232 | 0.91 | 4.0 | 4.2 | 7.8 | 65.0 | 29 | 15 | 12 | 3 | 30 | 56 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 3.26 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 35 | 0 | 2 | 3 | 2.72 | .292 | 1.21 | 6.8 | 4.3 | 10.0 | 36.1 | 27 | 14 | 11 | 4 | 17 | 40 | 0 | 4 | 0 | 0 | 0 | 1 | 2 | 3.72 |