| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 15 | 15 | 12 | 3 | 2.44 | .228 | 0.87 | 5.7 | 2.2 | 8.4 | 125.1 | 79 | 35 | 34 | 10 | 30 | 116 | 8 | 0 | 0 | 2 | 11 | 2 | 1 | 2.95 |
| SP | Leonard, D.Leonard, Dutch # >> | 22 | 1914 | L | 91 | 13 | 13 | 5 | 5 | 4.11 | .297 | 1.24 | 8.4 | 2.9 | 4.7 | 85.1 | 79 | 39 | 39 | 9 | 27 | 44 | 0 | 0 | 0 | 0 | 10 | 2 | 1 | 4.36 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 8 | 8 | 5 | 2 | 3.78 | .293 | 1.23 | 6.5 | 4.6 | 3.5 | 66.2 | 48 | 28 | 28 | 3 | 34 | 26 | 4 | 0 | 0 | 1 | 4 | 1 | 1 | 4.39 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 43 | 0 | 2 | 1 | 2.23 | .205 | 0.77 | 4.5 | 2.5 | 7.9 | 32.1 | 16 | 9 | 8 | 2 | 9 | 28 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.91 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 44 | 0 | 0 | 0 | 1.31 | .202 | 0.67 | 3.2 | 2.9 | 9.3 | 34.1 | 12 | 5 | 5 | 1 | 11 | 35 | 0 | 3 | 0 | 0 | 0 | 3 | 0 | 2.56 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 32 | 32 | 0 | 3 | 1 | 2.92 | .245 | 0.97 | 4.9 | 4.1 | 7.5 | 24.2 | 13 | 9 | 8 | 2 | 11 | 20 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.79 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 31 | 0 | 0 | 2 | 7.23 | .417 | 2.14 | 13.0 | 7.0 | 12.0 | 18.2 | 26 | 18 | 15 | 5 | 14 | 24 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 6.28 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 35 | 18 | 0 | 2 | 0 | 0.90 | .189 | 0.70 | 5.4 | 0.9 | 5.4 | 10.0 | 6 | 1 | 1 | 0 | 1 | 6 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.10 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 14 | 0 | 0 | 1 | 3.00 | .357 | 1.67 | 7.5 | 7.5 | 9.0 | 6.0 | 5 | 2 | 2 | 1 | 5 | 6 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 5.67 |
| RP | Rocker, J.Rocker, John >> | 25 | 1999 | L | 29 | 6 | 0 | 0 | 0 | 0.00 | .208 | 0.79 | 6.0 | 1.5 | 9.0 | 6.1 | 4 | 0 | 0 | 0 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.50 |
| RP | Kim, B.Kim, Byung-Hyun >> | 22 | 2001 | R | 45 | 14 | 0 | 2 | 0 | 1.29 | .300 | 1.29 | 4.5 | 7.1 | 7.1 | 14.0 | 7 | 2 | 2 | 0 | 11 | 11 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.79 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 18 | 0 | 4 | 4 | 1.64 | .229 | 0.89 | 4.6 | 3.5 | 5.9 | 49.1 | 25 | 9 | 9 | 3 | 19 | 32 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.65 |