| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 30 | 30 | 19 | 5 | 2.24 | .232 | 0.90 | 6.3 | 1.8 | 9.4 | 221.0 | 155 | 57 | 55 | 17 | 44 | 231 | 3 | 0 | 0 | 2 | 21 | 1 | 0 | 2.52 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 29 | 29 | 14 | 7 | 4.11 | .323 | 1.41 | 8.0 | 4.7 | 3.8 | 201.1 | 178 | 94 | 92 | 19 | 106 | 84 | 3 | 0 | 0 | 0 | 15 | 4 | 3 | 5.03 |
| SP | Lundgren, C.Lundgren, Carl † >> | 27 | 1907 | R | 42 | 28 | 28 | 16 | 7 | 2.57 | .268 | 1.07 | 6.1 | 3.5 | 4.0 | 213.1 | 145 | 64 | 61 | 11 | 83 | 95 | 7 | 0 | 0 | 1 | 23 | 6 | 3 | 4.03 |
| RP | Miller, A.Miller, Andrew >> | 32 | 2017 | L | 85 | 80 | 0 | 7 | 2 | 1.84 | .271 | 1.07 | 6.7 | 3.0 | 8.1 | 63.2 | 47 | 13 | 13 | 4 | 21 | 57 | 0 | 3 | 1 | 0 | 0 | 3 | 0 | 3.16 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 81 | 0 | 5 | 2 | 0.99 | .204 | 0.73 | 3.8 | 2.9 | 8.8 | 72.2 | 30 | 9 | 8 | 1 | 23 | 70 | 0 | 9 | 0 | 0 | 0 | 3 | 2 | 2.32 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 62 | 0 | 4 | 0 | 3.61 | .310 | 1.35 | 7.5 | 4.7 | 7.7 | 42.1 | 35 | 17 | 17 | 3 | 22 | 36 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.79 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 32 | 44 | 0 | 8 | 0 | 1.41 | .263 | 1.07 | 5.4 | 4.3 | 6.4 | 38.1 | 23 | 6 | 6 | 1 | 18 | 27 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.34 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 47 | 0 | 1 | 0 | 2.31 | .264 | 1.08 | 5.1 | 4.6 | 7.4 | 39.0 | 22 | 11 | 10 | 3 | 20 | 32 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.90 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 61 | 41 | 0 | 3 | 2 | 3.32 | .274 | 1.13 | 6.7 | 3.6 | 9.0 | 43.1 | 32 | 18 | 16 | 7 | 17 | 43 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 4.30 |