| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 8 | 8 | 2 | 2 | 5.09 | .330 | 1.48 | 10.4 | 3.2 | 9.7 | 40.2 | 46 | 24 | 23 | 4 | 14 | 43 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 3.20 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 8 | 8 | 2 | 2 | 4.50 | .304 | 1.31 | 8.3 | 3.5 | 6.9 | 52.0 | 48 | 31 | 26 | 8 | 20 | 40 | 1 | 0 | 0 | 0 | 3 | 0 | 3 | 4.62 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 7 | 7 | 4 | 2 | 5.48 | .363 | 1.69 | 10.7 | 4.7 | 7.1 | 42.2 | 50 | 29 | 26 | 2 | 22 | 33 | 1 | 0 | 0 | 0 | 3 | 1 | 1 | 3.69 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 19 | 0 | 3 | 0 | 2.67 | .214 | 0.81 | 5.3 | 2.0 | 8.3 | 27.0 | 16 | 8 | 8 | 2 | 6 | 25 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.78 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 13 | 0 | 0 | 2 | 8.31 | .400 | 2.00 | 12.5 | 5.5 | 9.0 | 13.0 | 18 | 14 | 12 | 2 | 8 | 13 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 4.85 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 1 | 0 | 0 | 0 | 0.00 | .273 | 1.13 | 13.5 | 0.0 | 9.0 | 2.2 | 3 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 65 | 3 | 0 | 0 | 0 | 2.25 | .294 | 1.25 | 6.8 | 4.5 | 9.0 | 4.0 | 3 | 1 | 1 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.50 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 5 | 0 | 1 | 1 | 3.58 | .272 | 1.12 | 5.7 | 4.7 | 8.0 | 27.2 | 17 | 11 | 11 | 2 | 14 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.74 |