| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 15 | 15 | 7 | 4 | 3.33 | .285 | 1.18 | 7.8 | 2.8 | 8.7 | 92.0 | 80 | 36 | 34 | 13 | 29 | 89 | 0 | 0 | 0 | 0 | 11 | 1 | 0 | 3.88 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 14 | 14 | 6 | 6 | 4.82 | .334 | 1.51 | 10.8 | 2.8 | 3.7 | 89.2 | 107 | 53 | 48 | 7 | 28 | 37 | 2 | 0 | 0 | 0 | 8 | 0 | 2 | 4.13 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 14 | 14 | 6 | 1 | 5.03 | .288 | 1.20 | 9.0 | 1.8 | 8.8 | 73.1 | 73 | 45 | 41 | 15 | 15 | 71 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 4.38 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 14 | 14 | 6 | 5 | 3.73 | .295 | 1.24 | 8.5 | 2.7 | 6.3 | 99.0 | 93 | 46 | 41 | 11 | 30 | 69 | 4 | 0 | 0 | 1 | 6 | 1 | 0 | 3.99 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 14 | 14 | 4 | 6 | 5.85 | .356 | 1.64 | 11.1 | 3.8 | 8.7 | 67.2 | 83 | 45 | 44 | 9 | 28 | 65 | 0 | 0 | 0 | 0 | 7 | 1 | 4 | 4.10 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 33 | 0 | 1 | 2 | 3.11 | .285 | 1.19 | 7.8 | 3.2 | 9.0 | 37.2 | 32 | 14 | 13 | 7 | 13 | 37 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.51 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 14 | 0 | 1 | 0 | 0.54 | .265 | 0.96 | 3.4 | 5.6 | 8.4 | 16.2 | 6 | 1 | 1 | 1 | 10 | 15 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 4.19 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 12 | 0 | 0 | 2 | 4.91 | .353 | 1.64 | 9.0 | 5.7 | 13.9 | 11.0 | 11 | 6 | 6 | 3 | 7 | 17 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5.36 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 16 | 0 | 1 | 0 | 1.98 | .234 | 0.91 | 6.0 | 2.3 | 6.3 | 27.1 | 18 | 6 | 6 | 1 | 7 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.85 |