| SP | McNally, D.McNally, Dave # >> | 26 | 1968 | L | 96 | 26 | 26 | 12 | 10 | 3.72 | .287 | 1.19 | 8.3 | 2.4 | 5.7 | 191.0 | 176 | 79 | 79 | 21 | 51 | 120 | 7 | 0 | 0 | 2 | 15 | 4 | 2 | 4.04 |
| SP | Santana, J.Santana, Johan † >> | 25 | 2004 | L | 86 | 25 | 25 | 9 | 9 | 5.22 | .314 | 1.36 | 9.2 | 3.0 | 7.6 | 153.1 | 157 | 90 | 89 | 25 | 51 | 130 | 3 | 0 | 0 | 3 | 11 | 3 | 2 | 4.48 |
| SP | Bender, C.Bender, Chief # >> | 26 | 1910 | R | 72 | 25 | 25 | 5 | 12 | 6.69 | .358 | 1.64 | 11.0 | 3.8 | 4.9 | 153.1 | 187 | 121 | 114 | 17 | 65 | 84 | 5 | 0 | 0 | 0 | 6 | 4 | 4 | 4.70 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 24 | 24 | 5 | 10 | 6.14 | .358 | 1.64 | 10.7 | 4.1 | 4.6 | 139.1 | 165 | 100 | 95 | 25 | 63 | 71 | 1 | 0 | 0 | 0 | 7 | 5 | 3 | 5.78 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 24 | 24 | 5 | 7 | 6.12 | .362 | 1.67 | 9.2 | 5.9 | 8.2 | 114.2 | 116 | 78 | 78 | 15 | 75 | 104 | 0 | 0 | 0 | 0 | 2 | 4 | 2 | 4.96 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 65 | 0 | 7 | 4 | 3.87 | .297 | 1.25 | 8.1 | 3.2 | 9.5 | 90.2 | 81 | 40 | 39 | 10 | 32 | 95 | 0 | 6 | 5 | 0 | 0 | 2 | 1 | 3.47 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 55 | 0 | 5 | 3 | 3.89 | .300 | 1.26 | 7.7 | 3.7 | 6.0 | 78.2 | 67 | 37 | 34 | 9 | 32 | 52 | 0 | 2 | 4 | 0 | 0 | 2 | 0 | 4.47 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 54 | 0 | 3 | 3 | 4.53 | .329 | 1.44 | 7.4 | 5.7 | 6.0 | 57.2 | 47 | 30 | 29 | 9 | 36 | 38 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 5.72 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 5 | 0 | 2 | 0 | 1.17 | .258 | 1.04 | 6.4 | 3.9 | 6.4 | 7.2 | 5 | 1 | 1 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.86 |
| SP | Cuellar, M.Cuellar, Mike >> | 32 | 1969 | L | 44 | 36 | 0 | 5 | 2 | 5.37 | .339 | 1.51 | 9.4 | 4.2 | 5.5 | 67.0 | 70 | 40 | 40 | 13 | 31 | 41 | 0 | 7 | 0 | 0 | 0 | 2 | 1 | 5.78 |