| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 26 | 26 | 10 | 11 | 3.74 | .312 | 1.35 | 8.2 | 4.0 | 7.2 | 192.2 | 174 | 85 | 80 | 14 | 86 | 154 | 4 | 0 | 0 | 1 | 16 | 2 | 5 | 3.72 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 25 | 25 | 8 | 10 | 5.33 | .331 | 1.46 | 9.1 | 4.0 | 5.2 | 150.1 | 152 | 91 | 89 | 20 | 67 | 87 | 2 | 0 | 0 | 0 | 15 | 4 | 1 | 4.99 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 25 | 25 | 8 | 14 | 5.14 | .341 | 1.53 | 9.8 | 4.0 | 4.8 | 171.2 | 187 | 107 | 98 | 21 | 76 | 92 | 9 | 0 | 0 | 1 | 12 | 4 | 2 | 4.92 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 24 | 24 | 7 | 13 | 4.53 | .310 | 1.32 | 9.1 | 2.9 | 6.9 | 161.0 | 162 | 86 | 81 | 25 | 51 | 123 | 2 | 0 | 0 | 0 | 10 | 4 | 7 | 4.52 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 22 | 22 | 10 | 10 | 4.50 | .319 | 1.39 | 10.2 | 2.3 | 4.4 | 166.0 | 188 | 95 | 83 | 19 | 43 | 82 | 8 | 0 | 0 | 0 | 10 | 2 | 3 | 4.31 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 95 | 65 | 0 | 4 | 3 | 2.57 | .284 | 1.19 | 4.7 | 6.0 | 8.6 | 84.0 | 44 | 31 | 24 | 7 | 56 | 80 | 0 | 5 | 3 | 0 | 0 | 0 | 2 | 4.18 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 49 | 0 | 2 | 1 | 3.25 | .262 | 1.07 | 7.2 | 2.4 | 9.1 | 61.0 | 49 | 22 | 22 | 11 | 16 | 62 | 0 | 9 | 1 | 0 | 0 | 0 | 0 | 4.10 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 33 | 0 | 1 | 3 | 5.15 | .364 | 1.66 | 6.8 | 8.5 | 8.8 | 36.2 | 27 | 23 | 21 | 5 | 34 | 35 | 0 | 3 | 1 | 0 | 0 | 2 | 3 | 5.86 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 25 | 0 | 2 | 3 | 6.07 | .360 | 1.65 | 9.9 | 5.3 | 9.0 | 29.2 | 32 | 20 | 20 | 5 | 17 | 29 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 5.10 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 1 | 0 | 1 | 5.14 | .364 | 1.71 | 10.3 | 5.1 | 6.4 | 7.0 | 8 | 4 | 4 | 1 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.14 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 54 | 5 | 0 | 0 | 1 | 8.53 | .500 | 2.53 | 16.5 | 7.5 | 6.0 | 6.1 | 11 | 6 | 6 | 2 | 5 | 4 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 10.00 |