| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 26 | 26 | 8 | 10 | 3.57 | .270 | 1.09 | 8.2 | 1.7 | 7.9 | 171.1 | 155 | 70 | 68 | 21 | 32 | 151 | 7 | 0 | 0 | 4 | 17 | 3 | 4 | 3.44 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 90 | 25 | 25 | 13 | 7 | 3.49 | .286 | 1.18 | 8.1 | 2.6 | 8.8 | 172.2 | 154 | 69 | 67 | 20 | 50 | 168 | 3 | 0 | 0 | 1 | 17 | 3 | 6 | 3.48 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 24 | 24 | 11 | 8 | 4.78 | .324 | 1.41 | 9.0 | 3.7 | 5.9 | 141.1 | 141 | 81 | 75 | 16 | 58 | 93 | 2 | 0 | 0 | 1 | 12 | 4 | 2 | 4.48 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 25 | 23 | 9 | 5 | 4.51 | .317 | 1.38 | 8.7 | 3.8 | 7.5 | 135.2 | 130 | 72 | 68 | 22 | 57 | 112 | 2 | 0 | 0 | 1 | 11 | 2 | 3 | 4.77 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 60 | 0 | 8 | 5 | 3.04 | .311 | 1.32 | 8.3 | 3.6 | 7.9 | 68.0 | 63 | 29 | 23 | 8 | 27 | 60 | 0 | 17 | 5 | 0 | 0 | 2 | 0 | 4.04 |
| SU | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 94 | 66 | 0 | 6 | 1 | 3.90 | .297 | 1.23 | 7.0 | 4.1 | 10.8 | 85.1 | 66 | 37 | 37 | 8 | 39 | 102 | 0 | 4 | 4 | 0 | 0 | 3 | 0 | 3.31 |
| RP | Papelbon, J.Papelbon, Jonathan # >> | 27 | 2007 | R | 92 | 67 | 0 | 4 | 3 | 5.30 | .356 | 1.64 | 9.5 | 5.3 | 9.7 | 73.0 | 77 | 44 | 43 | 8 | 43 | 79 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 4.07 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 49 | 0 | 1 | 1 | 5.34 | .337 | 1.47 | 8.2 | 5.2 | 7.2 | 55.2 | 50 | 35 | 33 | 5 | 32 | 44 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 4.49 |