| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 37 | 37 | 16 | 13 | 3.39 | .292 | 1.22 | 7.8 | 3.2 | 9.3 | 233.1 | 201 | 101 | 88 | 23 | 83 | 240 | 5 | 0 | 0 | 1 | 23 | 5 | 3 | 3.36 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 34 | 34 | 13 | 11 | 5.14 | .330 | 1.46 | 9.9 | 3.3 | 4.3 | 201.1 | 221 | 126 | 115 | 27 | 73 | 97 | 3 | 0 | 0 | 0 | 14 | 4 | 2 | 4.93 |
| CL | Uehara, K.Uehara, Koji † $ >> | 38 | 2013 | R | 100 | 92 | 0 | 7 | 7 | 2.84 | .257 | 1.03 | 6.9 | 2.4 | 9.3 | 101.1 | 77 | 34 | 32 | 13 | 27 | 104 | 0 | 41 | 3 | 0 | 0 | 1 | 3 | 3.45 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 98 | 0 | 5 | 2 | 3.98 | .307 | 1.31 | 8.1 | 3.8 | 9.0 | 115.1 | 103 | 53 | 51 | 19 | 48 | 115 | 0 | 3 | 5 | 0 | 0 | 2 | 0 | 4.45 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 79 | 0 | 9 | 2 | 3.82 | .267 | 1.06 | 8.0 | 1.5 | 8.4 | 99.0 | 88 | 43 | 42 | 16 | 17 | 92 | 0 | 3 | 1 | 0 | 0 | 3 | 1 | 3.85 |