| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 26 | 26 | 11 | 9 | 3.77 | .294 | 1.21 | 8.4 | 2.6 | 8.6 | 181.1 | 168 | 80 | 76 | 15 | 52 | 172 | 2 | 0 | 0 | 0 | 16 | 7 | 2 | 3.15 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 25 | 25 | 11 | 11 | 4.76 | .302 | 1.27 | 9.2 | 2.2 | 4.8 | 181.2 | 185 | 100 | 96 | 20 | 45 | 96 | 4 | 0 | 0 | 0 | 9 | 6 | 3 | 4.22 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 72 | 24 | 24 | 12 | 8 | 4.36 | .298 | 1.26 | 8.5 | 2.8 | 4.5 | 157.0 | 149 | 78 | 76 | 19 | 49 | 79 | 0 | 0 | 0 | 0 | 12 | 2 | 1 | 4.54 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 63 | 23 | 23 | 8 | 7 | 5.15 | .320 | 1.40 | 9.6 | 3.1 | 5.2 | 157.1 | 167 | 101 | 90 | 26 | 54 | 90 | 1 | 0 | 0 | 0 | 8 | 1 | 2 | 5.06 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 68 | 0 | 4 | 2 | 3.14 | .255 | 0.97 | 6.3 | 2.5 | 8.1 | 94.2 | 66 | 36 | 33 | 13 | 26 | 85 | 0 | 12 | 0 | 0 | 0 | 5 | 1 | 3.98 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 49 | 0 | 2 | 5 | 3.27 | .313 | 1.31 | 8.2 | 3.6 | 9.2 | 55.0 | 50 | 22 | 20 | 6 | 22 | 56 | 0 | 11 | 4 | 0 | 0 | 3 | 1 | 3.75 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 30 | 0 | 2 | 5 | 3.52 | .315 | 1.36 | 9.0 | 3.3 | 7.8 | 38.1 | 38 | 17 | 15 | 5 | 14 | 33 | 0 | 3 | 3 | 0 | 0 | 1 | 2 | 4.16 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 56 | 21 | 0 | 0 | 1 | 6.29 | .330 | 1.48 | 9.8 | 3.8 | 8.3 | 24.1 | 26 | 17 | 17 | 5 | 10 | 22 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.13 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 5 | 1 | 0 | 2 | 3.52 | .333 | 1.50 | 10.2 | 3.6 | 5.4 | 15.1 | 17 | 7 | 6 | 0 | 6 | 9 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 3.00 |