| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 10 | 10 | 3 | 5 | 3.91 | .289 | 1.20 | 8.2 | 2.6 | 9.5 | 69.0 | 63 | 30 | 30 | 10 | 20 | 73 | 1 | 0 | 0 | 0 | 5 | 1 | 0 | 3.68 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 9 | 9 | 3 | 3 | 3.57 | .284 | 1.19 | 7.9 | 2.9 | 4.4 | 63.0 | 55 | 27 | 25 | 3 | 20 | 31 | 0 | 0 | 0 | 0 | 7 | 0 | 1 | 3.59 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 10 | 10 | 4 | 6 | 5.23 | .323 | 1.39 | 9.7 | 2.8 | 5.8 | 74.0 | 80 | 45 | 43 | 12 | 23 | 48 | 2 | 0 | 0 | 0 | 4 | 3 | 2 | 4.86 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 24 | 0 | 2 | 1 | 7.46 | .315 | 1.38 | 9.7 | 2.9 | 8.3 | 25.1 | 27 | 21 | 21 | 6 | 8 | 23 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 5.24 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 13 | 0 | 2 | 0 | 2.12 | .292 | 1.24 | 5.8 | 5.3 | 7.9 | 17.0 | 11 | 4 | 4 | 1 | 10 | 15 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 3.76 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 13 | 0 | 0 | 0 | 7.04 | .373 | 1.78 | 8.6 | 7.4 | 7.8 | 23.0 | 22 | 19 | 18 | 5 | 19 | 20 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 6.57 |
| SP | Russell, R.Russell, Reb >> | 27 | 1916 | L | 52 | 4 | 2 | 1 | 1 | 12.19 | .426 | 2.23 | 16.2 | 4.5 | 4.5 | 10.1 | 18 | 14 | 14 | 4 | 5 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 8.70 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 5 | 1 | 1 | 0 | 4.09 | .233 | 0.91 | 5.7 | 2.5 | 2.5 | 11.0 | 7 | 5 | 5 | 3 | 3 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 6.82 |