| SP | deGrom, J.deGrom, Jacob † # >> | 33 | 2021 | R | 100 | 26 | 26 | 12 | 7 | 3.49 | .284 | 1.16 | 8.4 | 2.1 | 9.7 | 170.1 | 158 | 71 | 66 | 19 | 40 | 183 | 0 | 0 | 0 | 0 | 17 | 5 | 0 | 3.09 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 25 | 25 | 7 | 7 | 5.41 | .341 | 1.52 | 10.7 | 3.0 | 8.3 | 146.1 | 174 | 93 | 88 | 23 | 48 | 134 | 1 | 0 | 0 | 0 | 11 | 5 | 0 | 4.30 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 25 | 23 | 9 | 9 | 4.42 | .327 | 1.44 | 8.2 | 4.8 | 3.6 | 136.1 | 124 | 74 | 67 | 15 | 72 | 55 | 1 | 0 | 0 | 0 | 13 | 3 | 3 | 5.28 |
| RP | Rivera, M.Rivera, Mariano # >> | 39 | 2008 | R | 85 | 77 | 0 | 6 | 2 | 5.14 | .299 | 1.26 | 9.5 | 1.9 | 7.0 | 96.1 | 101 | 60 | 55 | 15 | 20 | 75 | 0 | 2 | 1 | 0 | 0 | 2 | 1 | 4.16 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 57 | 0 | 3 | 5 | 6.17 | .354 | 1.63 | 8.8 | 5.9 | 8.2 | 58.1 | 57 | 43 | 40 | 9 | 38 | 53 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 5.21 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 50 | 0 | 2 | 1 | 4.93 | .370 | 1.68 | 9.7 | 5.5 | 8.8 | 49.1 | 53 | 31 | 27 | 9 | 30 | 48 | 0 | 2 | 4 | 0 | 0 | 4 | 5 | 5.51 |
| CL | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 93 | 62 | 0 | 3 | 12 | 4.18 | .315 | 1.38 | 7.6 | 4.9 | 8.7 | 79.2 | 67 | 48 | 37 | 10 | 43 | 76 | 0 | 16 | 10 | 0 | 0 | 0 | 5 | 4.35 |