| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 26 | 26 | 10 | 9 | 3.23 | .278 | 1.13 | 7.1 | 3.1 | 8.8 | 175.2 | 139 | 71 | 63 | 23 | 60 | 171 | 6 | 0 | 0 | 1 | 18 | 4 | 4 | 3.85 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 25 | 25 | 11 | 9 | 3.80 | .287 | 1.20 | 8.6 | 2.2 | 4.8 | 168.0 | 161 | 78 | 71 | 11 | 41 | 89 | 2 | 0 | 0 | 1 | 15 | 1 | 3 | 3.54 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 24 | 24 | 7 | 6 | 5.67 | .340 | 1.54 | 11.1 | 2.8 | 8.0 | 127.0 | 156 | 86 | 80 | 21 | 40 | 113 | 0 | 0 | 0 | 0 | 11 | 0 | 4 | 4.31 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 67 | 0 | 3 | 3 | 4.14 | .325 | 1.41 | 9.1 | 3.6 | 7.8 | 76.0 | 77 | 39 | 35 | 14 | 30 | 66 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 4.96 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 54 | 0 | 3 | 0 | 4.60 | .352 | 1.58 | 9.0 | 5.4 | 8.4 | 60.2 | 60 | 39 | 31 | 7 | 36 | 56 | 0 | 2 | 0 | 0 | 0 | 3 | 3 | 4.60 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 44 | 0 | 6 | 2 | 5.44 | .338 | 1.51 | 9.4 | 4.3 | 7.2 | 46.1 | 48 | 28 | 28 | 6 | 22 | 37 | 0 | 1 | 1 | 0 | 0 | 1 | 4 | 4.59 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 34 | 0 | 3 | 0 | 2.50 | .265 | 1.08 | 7.2 | 2.8 | 7.2 | 39.2 | 31 | 13 | 11 | 5 | 12 | 31 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.00 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 26 | 0 | 0 | 2 | 1.53 | .237 | 0.91 | 4.4 | 3.9 | 4.9 | 35.1 | 17 | 7 | 6 | 3 | 15 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.40 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 51 | 0 | 4 | 8 | 3.60 | .283 | 1.13 | 7.0 | 3.1 | 10.3 | 55.0 | 43 | 24 | 22 | 8 | 19 | 63 | 0 | 27 | 3 | 0 | 0 | 3 | 4 | 3.80 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 45 | 0 | 0 | 2 | 3.55 | .248 | 0.95 | 7.7 | 0.9 | 7.2 | 50.2 | 43 | 22 | 20 | 6 | 5 | 40 | 0 | 3 | 4 | 0 | 0 | 2 | 0 | 3.38 |