| SP | deGrom, J.deGrom, Jacob † $ >> | 33 | 2021 | R | 100 | 36 | 36 | 15 | 8 | 3.00 | .254 | 0.99 | 6.7 | 2.2 | 8.6 | 246.1 | 182 | 90 | 82 | 22 | 61 | 234 | 0 | 0 | 0 | 0 | 28 | 8 | 0 | 3.10 |
| SP | Maddux, G.Maddux, Greg $$ >> | 29 | 1995 | R | 89 | 35 | 35 | 14 | 6 | 3.67 | .289 | 1.19 | 8.6 | 2.1 | 5.1 | 228.0 | 218 | 100 | 93 | 17 | 53 | 129 | 3 | 0 | 0 | 1 | 22 | 7 | 2 | 3.63 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 34 | 34 | 10 | 13 | 4.59 | .302 | 1.28 | 8.3 | 3.2 | 7.1 | 190.1 | 176 | 104 | 97 | 26 | 67 | 150 | 0 | 0 | 0 | 0 | 13 | 4 | 8 | 4.32 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 33 | 33 | 14 | 12 | 4.18 | .288 | 1.20 | 8.0 | 2.8 | 7.8 | 226.1 | 201 | 109 | 105 | 27 | 70 | 195 | 7 | 0 | 0 | 1 | 18 | 4 | 2 | 3.81 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 88 | 0 | 7 | 6 | 2.85 | .307 | 1.32 | 6.1 | 5.9 | 10.0 | 110.2 | 74 | 35 | 35 | 10 | 72 | 122 | 0 | 10 | 5 | 0 | 0 | 1 | 2 | 3.95 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 85 | 0 | 4 | 4 | 3.01 | .264 | 1.06 | 6.1 | 3.4 | 9.1 | 107.2 | 73 | 37 | 36 | 9 | 41 | 108 | 0 | 17 | 5 | 0 | 0 | 2 | 4 | 3.28 |
| RP | Soriano, R.Soriano, Rafael # >> | 24 | 2003 | R | 84 | 65 | 0 | 8 | 5 | 4.35 | .304 | 1.30 | 8.8 | 3.0 | 8.3 | 78.2 | 76 | 38 | 38 | 11 | 26 | 72 | 0 | 6 | 3 | 0 | 0 | 1 | 0 | 4.03 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 52 | 0 | 7 | 2 | 1.82 | .270 | 1.10 | 5.8 | 4.1 | 5.5 | 59.1 | 38 | 13 | 12 | 3 | 27 | 36 | 0 | 7 | 2 | 0 | 0 | 1 | 0 | 3.86 |