| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 21 | 21 | 2 | 11 | 6.77 | .351 | 1.61 | 10.4 | 4.2 | 8.5 | 103.2 | 119 | 81 | 78 | 21 | 48 | 97 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 5.19 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 19 | 19 | 9 | 5 | 3.53 | .286 | 1.20 | 8.3 | 2.5 | 3.8 | 148.0 | 136 | 64 | 58 | 12 | 41 | 63 | 5 | 0 | 0 | 2 | 11 | 1 | 3 | 4.05 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 73 | 21 | 21 | 7 | 11 | 4.28 | .282 | 1.17 | 8.3 | 2.3 | 4.3 | 157.2 | 145 | 85 | 75 | 14 | 40 | 75 | 7 | 0 | 0 | 1 | 10 | 1 | 0 | 3.99 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 71 | 21 | 21 | 4 | 7 | 5.32 | .338 | 1.50 | 10.4 | 3.2 | 4.1 | 130.1 | 150 | 82 | 77 | 15 | 46 | 59 | 2 | 0 | 0 | 0 | 10 | 4 | 2 | 4.75 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 54 | 0 | 3 | 1 | 3.93 | .250 | 0.97 | 7.0 | 1.8 | 8.5 | 71.0 | 55 | 32 | 31 | 10 | 14 | 67 | 0 | 9 | 4 | 0 | 0 | 2 | 3 | 3.62 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 45 | 0 | 3 | 4 | 3.82 | .290 | 1.19 | 8.7 | 2.1 | 8.9 | 61.1 | 59 | 30 | 26 | 6 | 14 | 60 | 0 | 4 | 2 | 0 | 0 | 2 | 2 | 3.10 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 53 | 22 | 0 | 4 | 1 | 4.40 | .338 | 1.53 | 11.9 | 2.3 | 4.8 | 28.2 | 37 | 17 | 14 | 5 | 7 | 15 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.00 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 2 | 2 | 0 | 2 | 6.23 | .328 | 1.38 | 6.9 | 5.5 | 10.4 | 13.0 | 10 | 11 | 9 | 2 | 8 | 15 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4.77 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 10 | 0 | 0 | 1 | 3.38 | .326 | 1.41 | 8.6 | 4.3 | 5.6 | 21.1 | 20 | 10 | 8 | 4 | 10 | 13 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 5.81 |