| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 34 | 34 | 9 | 13 | 4.74 | .321 | 1.39 | 8.7 | 3.9 | 8.4 | 214.2 | 207 | 115 | 113 | 24 | 92 | 200 | 0 | 0 | 0 | 0 | 17 | 5 | 5 | 3.95 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 31 | 31 | 3 | 15 | 5.28 | .333 | 1.45 | 9.3 | 3.8 | 6.4 | 187.1 | 194 | 111 | 110 | 24 | 78 | 134 | 0 | 0 | 0 | 0 | 11 | 8 | 6 | 4.61 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 26 | 20 | 5 | 14 | 6.61 | .344 | 1.56 | 10.2 | 3.8 | 5.4 | 143.0 | 162 | 105 | 105 | 23 | 61 | 86 | 4 | 0 | 0 | 1 | 4 | 2 | 0 | 5.21 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 32 | 32 | 13 | 12 | 5.29 | .343 | 1.55 | 10.4 | 3.6 | 5.0 | 229.2 | 265 | 144 | 135 | 17 | 92 | 127 | 10 | 0 | 0 | 3 | 10 | 2 | 12 | 4.09 |
| SP | Clemens, R.Clemens, Roger $$ >> | 24 | 1986 | R | 69 | 32 | 30 | 11 | 15 | 4.25 | .324 | 1.43 | 9.3 | 3.6 | 6.4 | 235.1 | 242 | 112 | 111 | 24 | 94 | 166 | 8 | 0 | 0 | 1 | 13 | 2 | 6 | 4.14 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 85 | 0 | 3 | 3 | 2.67 | .283 | 1.18 | 6.5 | 4.1 | 8.6 | 111.1 | 80 | 35 | 33 | 9 | 51 | 106 | 0 | 8 | 3 | 0 | 0 | 1 | 4 | 3.55 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 71 | 0 | 5 | 11 | 4.01 | .307 | 1.33 | 10.7 | 1.3 | 6.4 | 89.2 | 106 | 43 | 40 | 9 | 13 | 63 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.34 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 81 | 54 | 0 | 2 | 5 | 6.07 | .345 | 1.58 | 10.1 | 4.2 | 8.8 | 56.1 | 63 | 41 | 38 | 15 | 26 | 55 | 0 | 5 | 4 | 0 | 0 | 0 | 1 | 5.91 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 37 | 0 | 2 | 3 | 3.33 | .296 | 1.24 | 7.0 | 4.1 | 8.2 | 46.0 | 36 | 17 | 17 | 3 | 21 | 42 | 0 | 2 | 2 | 0 | 0 | 1 | 2 | 3.46 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 20 | 15 | 6 | 10 | 5.96 | .329 | 1.42 | 9.7 | 3.2 | 5.5 | 108.2 | 116 | 73 | 72 | 16 | 38 | 66 | 5 | 1 | 0 | 3 | 4 | 6 | 1 | 4.93 |