| SP | Martinez, P.Martinez, Pedro $ >> | 29 | 2000 | R | 100 | 22 | 22 | 11 | 5 | 3.68 | .306 | 1.29 | 8.5 | 3.2 | 8.9 | 134.2 | 126 | 58 | 55 | 13 | 48 | 132 | 1 | 0 | 0 | 0 | 15 | 4 | 2 | 3.46 |
| SP | Sutton, D.Sutton, Don † # >> | 27 | 1972 | R | 82 | 21 | 21 | 9 | 4 | 2.08 | .255 | 1.03 | 6.7 | 2.5 | 5.2 | 160.0 | 119 | 51 | 37 | 8 | 45 | 92 | 8 | 0 | 0 | 4 | 17 | 0 | 4 | 3.34 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 21 | 21 | 9 | 8 | 5.18 | .311 | 1.33 | 9.2 | 2.7 | 5.3 | 125.0 | 128 | 76 | 72 | 17 | 38 | 73 | 6 | 0 | 0 | 1 | 9 | 3 | 3 | 4.58 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 21 | 21 | 4 | 7 | 5.02 | .315 | 1.37 | 8.8 | 3.6 | 7.5 | 114.2 | 111 | 64 | 64 | 19 | 46 | 95 | 2 | 0 | 0 | 2 | 9 | 1 | 4 | 4.74 |
| CL | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 49 | 0 | 5 | 8 | 5.37 | .362 | 1.67 | 8.8 | 6.2 | 9.3 | 57.0 | 56 | 37 | 34 | 8 | 39 | 59 | 0 | 12 | 4 | 0 | 0 | 2 | 0 | 4.91 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 53 | 0 | 1 | 2 | 4.01 | .327 | 1.44 | 8.7 | 4.3 | 9.0 | 58.1 | 56 | 30 | 26 | 6 | 28 | 58 | 0 | 4 | 4 | 0 | 0 | 1 | 0 | 3.84 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 55 | 0 | 3 | 1 | 4.60 | .343 | 1.55 | 9.6 | 4.5 | 7.4 | 62.2 | 66 | 33 | 32 | 6 | 31 | 51 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.16 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 39 | 0 | 2 | 0 | 4.83 | .335 | 1.51 | 8.1 | 5.6 | 8.3 | 50.1 | 45 | 27 | 27 | 9 | 31 | 46 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | 5.36 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 36 | 0 | 5 | 5 | 4.86 | .296 | 1.24 | 7.9 | 3.2 | 9.2 | 50.0 | 44 | 28 | 27 | 8 | 18 | 51 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 4.18 |