| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 33 | 33 | 11 | 9 | 4.98 | .311 | 1.34 | 9.9 | 2.2 | 8.2 | 191.2 | 210 | 115 | 106 | 36 | 47 | 175 | 1 | 0 | 0 | 0 | 15 | 2 | 5 | 4.39 |
| SP | Gibson, B.Gibson, Bob † # >> | 33 | 1968 | R | 92 | 33 | 32 | 18 | 6 | 4.42 | .308 | 1.31 | 8.0 | 3.9 | 5.7 | 199.2 | 176 | 100 | 98 | 22 | 86 | 127 | 4 | 0 | 0 | 2 | 16 | 5 | 4 | 4.53 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 33 | 32 | 12 | 9 | 5.89 | .334 | 1.49 | 10.3 | 3.1 | 8.5 | 178.2 | 204 | 121 | 117 | 28 | 62 | 168 | 3 | 0 | 0 | 0 | 12 | 3 | 2 | 4.25 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 31 | 30 | 10 | 8 | 5.31 | .332 | 1.48 | 10.2 | 3.2 | 6.2 | 171.1 | 194 | 112 | 101 | 31 | 60 | 117 | 4 | 0 | 0 | 0 | 12 | 1 | 3 | 5.06 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 32 | 30 | 10 | 15 | 5.53 | .342 | 1.54 | 9.7 | 4.3 | 6.0 | 167.2 | 180 | 123 | 103 | 25 | 79 | 112 | 2 | 0 | 0 | 1 | 13 | 2 | 3 | 5.06 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 90 | 0 | 3 | 7 | 2.53 | .261 | 1.03 | 6.8 | 2.5 | 8.7 | 106.2 | 80 | 33 | 30 | 12 | 30 | 103 | 0 | 33 | 4 | 0 | 0 | 3 | 0 | 3.46 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 93 | 0 | 7 | 3 | 3.26 | .290 | 1.21 | 7.4 | 3.5 | 8.7 | 110.1 | 91 | 44 | 40 | 12 | 43 | 106 | 0 | 5 | 5 | 0 | 0 | 1 | 0 | 3.69 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 87 | 0 | 10 | 5 | 3.92 | .285 | 1.18 | 7.2 | 3.4 | 11.2 | 101.0 | 81 | 45 | 44 | 10 | 38 | 126 | 0 | 3 | 3 | 0 | 0 | 2 | 7 | 2.98 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 95 | 0 | 6 | 3 | 4.90 | .333 | 1.47 | 9.5 | 3.8 | 8.0 | 97.1 | 102 | 58 | 53 | 11 | 41 | 86 | 0 | 0 | 2 | 0 | 0 | 3 | 9 | 4.06 |