| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 33 | 33 | 15 | 7 | 3.83 | .295 | 1.24 | 8.0 | 3.1 | 8.6 | 218.1 | 194 | 98 | 93 | 21 | 76 | 209 | 3 | 0 | 0 | 2 | 19 | 4 | 6 | 3.44 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 25 | 25 | 10 | 8 | 3.47 | .328 | 1.44 | 7.3 | 5.6 | 4.7 | 158.0 | 128 | 85 | 61 | 16 | 99 | 83 | 1 | 0 | 0 | 1 | 15 | 4 | 1 | 5.22 |
| SP | Maddux, G.Maddux, Greg # >> | 29 | 1995 | R | 89 | 30 | 27 | 16 | 5 | 3.78 | .300 | 1.27 | 9.9 | 1.6 | 6.8 | 185.2 | 203 | 86 | 78 | 17 | 32 | 139 | 4 | 0 | 0 | 1 | 16 | 4 | 2 | 3.28 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 85 | 0 | 5 | 3 | 3.48 | .288 | 1.20 | 6.6 | 4.3 | 6.3 | 93.0 | 68 | 44 | 36 | 14 | 44 | 65 | 0 | 11 | 1 | 0 | 0 | 1 | 0 | 5.01 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 96 | 0 | 3 | 0 | 4.46 | .348 | 1.58 | 8.7 | 5.7 | 9.4 | 70.2 | 68 | 43 | 35 | 11 | 44 | 73 | 0 | 3 | 2 | 0 | 0 | 1 | 3 | 4.89 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 69 | 0 | 7 | 4 | 4.44 | .283 | 1.17 | 7.8 | 2.8 | 8.2 | 81.0 | 70 | 42 | 40 | 7 | 25 | 74 | 0 | 0 | 3 | 0 | 0 | 1 | 2 | 3.26 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 56 | 0 | 5 | 4 | 3.68 | .308 | 1.32 | 6.7 | 5.3 | 8.0 | 73.1 | 54 | 32 | 30 | 8 | 43 | 65 | 0 | 2 | 4 | 0 | 0 | 1 | 0 | 4.45 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 49 | 0 | 3 | 2 | 4.61 | .307 | 1.29 | 6.8 | 5.0 | 8.3 | 52.2 | 39 | 27 | 27 | 4 | 29 | 48 | 0 | 3 | 1 | 0 | 0 | 2 | 3 | 3.94 |
| CL | Williams, D.Williams, Devin † >> | 28 | 2023 | R | 72 | 81 | 0 | 9 | 2 | 2.97 | .272 | 1.11 | 5.3 | 4.6 | 9.6 | 91.0 | 54 | 41 | 30 | 7 | 47 | 97 | 0 | 30 | 4 | 0 | 0 | 1 | 1 | 3.45 |