| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 96 | 33 | 33 | 16 | 7 | 3.27 | .270 | 1.08 | 7.2 | 2.6 | 6.2 | 217.2 | 173 | 83 | 79 | 25 | 62 | 149 | 2 | 0 | 0 | 1 | 24 | 6 | 3 | 4.06 |
| SP | Halladay, R.Halladay, Roy >> | 24 | 2001 | R | 80 | 33 | 33 | 9 | 13 | 3.89 | .317 | 1.36 | 9.4 | 2.8 | 6.5 | 206.0 | 215 | 96 | 89 | 20 | 65 | 149 | 0 | 0 | 0 | 0 | 19 | 7 | 4 | 3.86 |
| SP | Ortiz, R.Ortiz, Russ † >> | 27 | 2001 | R | 68 | 32 | 32 | 10 | 8 | 4.09 | .313 | 1.32 | 8.6 | 3.3 | 5.7 | 202.1 | 193 | 97 | 92 | 14 | 74 | 129 | 1 | 0 | 0 | 1 | 17 | 10 | 2 | 3.87 |
| SP | Williams, W.Williams, Woody # >> | 35 | 2001 | R | 46 | 31 | 31 | 12 | 8 | 5.48 | .329 | 1.41 | 9.8 | 2.9 | 5.5 | 184.0 | 201 | 112 | 112 | 35 | 59 | 113 | 0 | 0 | 0 | 0 | 16 | 11 | 2 | 5.39 |
| RP | Rivera, M.Rivera, Mariano † >> | 32 | 2001 | R | 93 | 105 | 0 | 9 | 5 | 1.72 | .234 | 0.88 | 6.1 | 1.9 | 8.7 | 130.2 | 88 | 27 | 25 | 11 | 27 | 125 | 0 | 10 | 5 | 0 | 0 | 5 | 2 | 2.92 |
| RP | Garces, R.Garces, Rich >> | 30 | 2001 | R | 70 | 79 | 0 | 2 | 5 | 3.42 | .316 | 1.34 | 7.3 | 4.9 | 5.7 | 73.2 | 59 | 35 | 28 | 9 | 40 | 46 | 0 | 11 | 2 | 0 | 0 | 3 | 1 | 5.11 |
| RP | Bottalico, R.Bottalico, Ricky >> | 32 | 2001 | R | 59 | 61 | 0 | 4 | 3 | 5.27 | .367 | 1.69 | 10.8 | 4.5 | 5.8 | 56.1 | 67 | 34 | 33 | 10 | 28 | 36 | 0 | 6 | 0 | 0 | 0 | 3 | 6 | 5.70 |