| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 95 | 33 | 33 | 17 | 7 | 3.40 | .289 | 1.21 | 7.6 | 3.2 | 7.9 | 225.0 | 191 | 90 | 85 | 16 | 81 | 198 | 4 | 0 | 0 | 1 | 21 | 2 | 9 | 3.27 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 32 | 32 | 10 | 15 | 5.33 | .313 | 1.34 | 9.2 | 2.9 | 8.1 | 189.0 | 193 | 113 | 112 | 27 | 61 | 171 | 3 | 0 | 0 | 0 | 13 | 4 | 7 | 4.08 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 76 | 31 | 31 | 13 | 11 | 4.41 | .320 | 1.40 | 10.1 | 2.5 | 9.2 | 179.2 | 201 | 91 | 88 | 29 | 50 | 182 | 1 | 0 | 0 | 1 | 16 | 3 | 4 | 3.96 |
| SP | Hendricks, K.Hendricks, Kyle # >> | 26 | 2016 | R | 73 | 26 | 26 | 12 | 9 | 3.91 | .275 | 1.11 | 7.9 | 2.2 | 6.8 | 149.2 | 130 | 70 | 65 | 17 | 36 | 112 | 2 | 0 | 0 | 1 | 15 | 4 | 1 | 3.79 |
| CL | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 93 | 61 | 0 | 4 | 11 | 2.90 | .268 | 1.10 | 6.9 | 3.0 | 9.0 | 68.1 | 52 | 24 | 22 | 10 | 23 | 68 | 0 | 31 | 2 | 0 | 0 | 0 | 1 | 3.93 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 76 | 0 | 1 | 3 | 3.61 | .268 | 1.07 | 8.1 | 1.6 | 9.5 | 84.2 | 76 | 35 | 34 | 10 | 15 | 89 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 3.04 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 80 | 75 | 0 | 2 | 2 | 4.39 | .339 | 1.49 | 10.2 | 3.4 | 9.9 | 67.2 | 76 | 33 | 33 | 8 | 25 | 74 | 0 | 1 | 2 | 0 | 0 | 3 | 6 | 3.60 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 54 | 0 | 1 | 2 | 2.68 | .266 | 1.05 | 6.3 | 3.2 | 10.3 | 57.0 | 40 | 19 | 17 | 6 | 20 | 65 | 0 | 2 | 2 | 0 | 0 | 2 | 2 | 3.25 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 69 | 39 | 0 | 1 | 2 | 5.91 | .340 | 1.55 | 8.4 | 5.8 | 7.9 | 42.2 | 39 | 30 | 28 | 6 | 27 | 37 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 5.02 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 67 | 13 | 4 | 4 | 1 | 4.86 | .329 | 1.47 | 10.1 | 3.3 | 6.8 | 33.1 | 37 | 20 | 18 | 1 | 12 | 25 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 2.97 |