| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 29 | 29 | 8 | 8 | 4.27 | .293 | 1.22 | 8.8 | 2.1 | 8.6 | 194.0 | 190 | 96 | 92 | 32 | 46 | 185 | 3 | 0 | 0 | 1 | 15 | 5 | 1 | 4.03 |
| SP | Wainwright, A.Wainwright, Adam >> | 29 | 2010 | R | 47 | 8 | 8 | 4 | 2 | 4.88 | .335 | 1.47 | 9.5 | 3.9 | 7.6 | 51.2 | 54 | 28 | 28 | 9 | 22 | 43 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 5.02 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 79 | 29 | 27 | 13 | 7 | 4.64 | .337 | 1.48 | 8.9 | 4.4 | 7.1 | 170.2 | 169 | 93 | 88 | 16 | 84 | 135 | 3 | 0 | 0 | 1 | 13 | 7 | 10 | 4.24 |
| SU | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 46 | 0 | 2 | 3 | 3.06 | .286 | 1.16 | 8.6 | 1.8 | 8.8 | 50.0 | 48 | 20 | 17 | 7 | 10 | 49 | 0 | 2 | 7 | 0 | 0 | 2 | 1 | 3.58 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 90 | 63 | 0 | 2 | 7 | 4.19 | .291 | 1.23 | 7.9 | 3.3 | 10.4 | 66.2 | 58 | 34 | 31 | 10 | 24 | 76 | 0 | 9 | 7 | 0 | 0 | 0 | 0 | 3.76 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 37 | 0 | 1 | 1 | 2.72 | .279 | 1.16 | 7.1 | 3.3 | 11.3 | 43.0 | 34 | 13 | 13 | 4 | 16 | 54 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2.81 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 40 | 17 | 0 | 3 | 0 | 2.49 | .261 | 1.06 | 6.0 | 3.9 | 10.3 | 21.2 | 14 | 7 | 6 | 3 | 9 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.86 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 69 | 34 | 0 | 5 | 0 | 4.30 | .280 | 1.14 | 7.5 | 2.9 | 4.9 | 37.2 | 31 | 19 | 18 | 5 | 12 | 20 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.73 |