| SP | deGrom, J.deGrom, Jacob † $ >> | 33 | 2021 | R | 100 | 29 | 29 | 18 | 5 | 2.59 | .257 | 1.02 | 7.0 | 2.2 | 10.4 | 198.1 | 154 | 62 | 57 | 18 | 49 | 228 | 1 | 0 | 0 | 1 | 24 | 3 | 0 | 2.67 |
| SP | Santana, J.Santana, Johan † # $$ >> | 25 | 2004 | L | 91 | 28 | 28 | 14 | 9 | 3.39 | .260 | 1.05 | 7.6 | 1.9 | 9.6 | 194.0 | 164 | 76 | 73 | 24 | 40 | 206 | 5 | 0 | 0 | 1 | 18 | 1 | 5 | 3.12 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 85 | 28 | 28 | 9 | 9 | 5.45 | .324 | 1.43 | 9.5 | 3.4 | 6.0 | 185.0 | 196 | 116 | 112 | 33 | 69 | 124 | 1 | 0 | 0 | 0 | 10 | 1 | 3 | 5.11 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 28 | 28 | 3 | 8 | 4.18 | .327 | 1.45 | 9.0 | 4.0 | 7.5 | 125.0 | 125 | 61 | 58 | 11 | 56 | 104 | 0 | 0 | 0 | 0 | 0 | 1 | 8 | 3.85 |
| SP | Perry, G.Perry, Gaylord # >> | 34 | 1972 | R | 69 | 28 | 28 | 12 | 8 | 4.62 | .321 | 1.40 | 9.0 | 3.5 | 5.8 | 187.0 | 188 | 99 | 96 | 33 | 73 | 121 | 6 | 0 | 0 | 1 | 13 | 4 | 6 | 5.24 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 98 | 72 | 0 | 4 | 5 | 2.92 | .283 | 1.18 | 6.8 | 3.9 | 9.2 | 77.0 | 58 | 28 | 25 | 4 | 33 | 79 | 0 | 40 | 3 | 0 | 0 | 0 | 5 | 2.91 |
| SU | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 92 | 60 | 0 | 3 | 4 | 3.50 | .309 | 1.33 | 7.3 | 4.7 | 10.3 | 69.1 | 56 | 29 | 27 | 4 | 36 | 79 | 0 | 6 | 5 | 0 | 0 | 1 | 2 | 3.07 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 73 | 0 | 10 | 4 | 2.83 | .263 | 1.02 | 5.4 | 3.8 | 9.7 | 86.0 | 52 | 27 | 27 | 9 | 36 | 93 | 0 | 3 | 5 | 0 | 0 | 4 | 6 | 3.59 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 76 | 48 | 0 | 2 | 3 | 1.64 | .257 | 1.01 | 6.5 | 2.7 | 7.9 | 71.1 | 51 | 14 | 13 | 7 | 21 | 62 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 3.51 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 71 | 52 | 0 | 3 | 2 | 4.40 | .295 | 1.21 | 6.9 | 4.0 | 7.8 | 61.1 | 47 | 30 | 30 | 8 | 27 | 53 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 4.44 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 63 | 17 | 0 | 2 | 4 | 9.00 | .405 | 2.00 | 14.2 | 3.8 | 6.2 | 26.0 | 41 | 26 | 26 | 7 | 11 | 18 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 6.50 |