| SP | deGrom, J.deGrom, Jacob † $$ >> | 33 | 2021 | R | 100 | 24 | 24 | 11 | 3 | 3.26 | .283 | 1.17 | 8.2 | 2.4 | 11.6 | 151.2 | 137 | 59 | 55 | 15 | 40 | 195 | 0 | 0 | 0 | 0 | 19 | 3 | 0 | 2.56 |
| SP | Santana, J.Santana, Johan $ >> | 25 | 2004 | L | 91 | 23 | 23 | 11 | 5 | 5.92 | .350 | 1.58 | 11.1 | 3.2 | 9.3 | 130.2 | 160 | 87 | 86 | 21 | 46 | 135 | 0 | 0 | 0 | 0 | 12 | 5 | 1 | 4.20 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 87 | 21 | 21 | 9 | 5 | 4.28 | .320 | 1.37 | 9.5 | 2.9 | 6.5 | 111.1 | 117 | 53 | 53 | 16 | 36 | 80 | 0 | 0 | 0 | 0 | 6 | 4 | 1 | 4.51 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 77 | 22 | 22 | 11 | 6 | 3.76 | .317 | 1.39 | 9.0 | 3.5 | 7.1 | 165.0 | 165 | 72 | 69 | 18 | 64 | 130 | 4 | 0 | 0 | 0 | 12 | 1 | 4 | 4.02 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 73 | 21 | 21 | 4 | 9 | 6.26 | .333 | 1.43 | 10.1 | 2.9 | 6.9 | 119.1 | 133 | 87 | 83 | 29 | 38 | 91 | 0 | 0 | 0 | 0 | 6 | 8 | 1 | 5.80 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 57 | 0 | 3 | 11 | 4.45 | .322 | 1.39 | 8.2 | 4.5 | 12.2 | 54.2 | 49 | 29 | 27 | 9 | 27 | 73 | 0 | 30 | 4 | 0 | 0 | 2 | 3 | 4.07 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 45 | 0 | 1 | 0 | 2.21 | .296 | 1.25 | 7.5 | 3.7 | 10.5 | 53.0 | 44 | 13 | 13 | 5 | 22 | 62 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 3.19 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 77 | 55 | 0 | 7 | 1 | 4.37 | .301 | 1.24 | 7.6 | 3.7 | 7.5 | 59.2 | 50 | 29 | 29 | 10 | 24 | 49 | 0 | 1 | 2 | 0 | 0 | 3 | 2 | 4.92 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 70 | 31 | 0 | 2 | 3 | 5.35 | .343 | 1.54 | 10.2 | 3.6 | 7.3 | 37.0 | 42 | 22 | 22 | 6 | 15 | 30 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.78 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 64 | 17 | 3 | 6 | 2 | 2.58 | .268 | 1.08 | 7.6 | 2.3 | 5.3 | 76.2 | 64 | 22 | 22 | 6 | 19 | 45 | 0 | 1 | 0 | 0 | 2 | 1 | 2 | 3.63 |