| SP | Koufax, S.Koufax, Sandy $ >> | 30 | 1965 | L | 97 | 24 | 24 | 7 | 11 | 4.36 | .311 | 1.33 | 9.0 | 3.0 | 8.6 | 175.1 | 175 | 93 | 85 | 18 | 59 | 167 | 5 | 0 | 0 | 0 | 11 | 3 | 9 | 3.49 |
| SP | Gibson, B.Gibson, Bob † $ >> | 33 | 1968 | R | 93 | 24 | 24 | 15 | 7 | 3.28 | .291 | 1.22 | 8.2 | 2.8 | 5.3 | 186.2 | 170 | 70 | 68 | 13 | 57 | 109 | 9 | 0 | 0 | 3 | 15 | 3 | 6 | 3.70 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 23 | 23 | 9 | 7 | 3.82 | .326 | 1.41 | 8.2 | 4.6 | 7.5 | 157.2 | 143 | 72 | 67 | 9 | 80 | 130 | 2 | 0 | 0 | 1 | 14 | 6 | 2 | 3.73 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 23 | 23 | 10 | 10 | 3.26 | .297 | 1.27 | 8.4 | 3.0 | 3.6 | 174.0 | 163 | 66 | 63 | 13 | 58 | 70 | 4 | 0 | 0 | 1 | 17 | 0 | 5 | 4.17 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 23 | 23 | 8 | 11 | 4.67 | .304 | 1.29 | 9.1 | 2.5 | 4.3 | 158.0 | 160 | 84 | 82 | 24 | 44 | 75 | 3 | 0 | 0 | 0 | 12 | 3 | 1 | 4.92 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 38 | 0 | 1 | 2 | 3.00 | .294 | 1.22 | 6.8 | 4.3 | 7.5 | 36.0 | 27 | 12 | 12 | 1 | 17 | 30 | 0 | 32 | 3 | 0 | 0 | 1 | 0 | 3.19 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 53 | 0 | 5 | 0 | 2.74 | .245 | 0.97 | 5.5 | 3.3 | 8.2 | 65.2 | 40 | 21 | 20 | 7 | 24 | 59 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 3.69 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 17 | 0 | 1 | 1 | 4.20 | .318 | 1.40 | 9.6 | 3.0 | 9.6 | 15.0 | 16 | 8 | 7 | 0 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.87 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 19 | 0 | 1 | 2 | 4.87 | .337 | 1.52 | 9.5 | 4.5 | 9.0 | 20.1 | 21 | 12 | 11 | 3 | 10 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.45 |