| SP | deGrom, J.deGrom, Jacob $$ >> | 33 | 2021 | R | 100 | 36 | 36 | 11 | 16 | 4.02 | .277 | 1.14 | 8.3 | 2.0 | 8.8 | 235.1 | 216 | 112 | 105 | 29 | 53 | 230 | 0 | 0 | 0 | 0 | 22 | 1 | 0 | 3.34 |
| SP | Scherzer, M.Scherzer, Max $$ >> | 33 | 2017 | R | 95 | 34 | 34 | 18 | 14 | 4.07 | .290 | 1.21 | 7.4 | 3.5 | 7.5 | 221.1 | 182 | 102 | 100 | 18 | 86 | 184 | 3 | 0 | 0 | 2 | 23 | 3 | 7 | 3.60 |
| SP | Kluber, C.Kluber, Corey $$ >> | 31 | 2017 | R | 89 | 33 | 33 | 9 | 13 | 5.38 | .337 | 1.50 | 10.5 | 3.0 | 8.3 | 195.2 | 228 | 124 | 117 | 20 | 65 | 179 | 1 | 0 | 0 | 0 | 15 | 6 | 7 | 3.59 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 33 | 33 | 12 | 14 | 4.80 | .307 | 1.29 | 8.0 | 3.6 | 4.7 | 217.2 | 193 | 124 | 116 | 28 | 87 | 114 | 8 | 0 | 0 | 2 | 15 | 9 | 3 | 4.95 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 31 | 31 | 11 | 14 | 5.46 | .337 | 1.50 | 10.7 | 2.9 | 5.4 | 202.2 | 240 | 128 | 123 | 37 | 64 | 121 | 5 | 0 | 0 | 0 | 12 | 5 | 3 | 5.21 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 66 | 0 | 6 | 3 | 2.21 | .288 | 1.19 | 4.6 | 6.2 | 10.4 | 73.1 | 37 | 19 | 18 | 2 | 50 | 84 | 0 | 38 | 3 | 0 | 0 | 2 | 2 | 3.19 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 55 | 0 | 6 | 0 | 4.20 | .283 | 1.17 | 7.5 | 3.0 | 8.6 | 60.0 | 50 | 29 | 28 | 6 | 20 | 57 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.45 |
| SU | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 62 | 0 | 2 | 3 | 2.84 | .286 | 1.15 | 6.3 | 4.1 | 9.3 | 63.1 | 44 | 20 | 20 | 9 | 29 | 65 | 0 | 6 | 4 | 0 | 0 | 3 | 2 | 4.32 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 41 | 0 | 2 | 1 | 2.44 | .304 | 1.27 | 7.7 | 3.8 | 8.3 | 48.0 | 41 | 13 | 13 | 3 | 20 | 44 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 3.35 |