| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 34 | 34 | 17 | 7 | 2.75 | .273 | 1.10 | 7.3 | 2.6 | 6.7 | 219.0 | 178 | 75 | 67 | 7 | 63 | 163 | 1 | 0 | 0 | 0 | 24 | 6 | 7 | 2.87 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 30 | 30 | 12 | 10 | 4.34 | .295 | 1.24 | 8.5 | 2.7 | 7.3 | 188.2 | 177 | 104 | 91 | 18 | 57 | 152 | 7 | 0 | 0 | 1 | 16 | 3 | 2 | 3.59 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 80 | 0 | 3 | 2 | 2.56 | .252 | 1.01 | 6.9 | 2.2 | 8.6 | 102.0 | 78 | 30 | 29 | 10 | 25 | 97 | 0 | 0 | 5 | 0 | 0 | 0 | 0 | 3.11 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 65 | 0 | 4 | 7 | 3.44 | .294 | 1.23 | 5.7 | 5.4 | 7.4 | 81.0 | 51 | 31 | 31 | 4 | 49 | 67 | 0 | 2 | 4 | 0 | 0 | 1 | 2 | 3.84 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 33 | 0 | 3 | 0 | 2.21 | .308 | 1.28 | 9.5 | 2.3 | 9.5 | 36.2 | 38 | 9 | 9 | 0 | 9 | 38 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 1.81 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 69 | 23 | 0 | 2 | 1 | 3.63 | .264 | 1.07 | 7.0 | 2.9 | 8.6 | 22.1 | 17 | 9 | 9 | 3 | 7 | 21 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.82 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 77 | 25 | 0 | 1 | 2 | 2.89 | .317 | 1.32 | 6.1 | 5.8 | 9.3 | 28.0 | 19 | 9 | 9 | 0 | 18 | 29 | 0 | 0 | 1 | 0 | 0 | 2 | 4 | 3.07 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 62 | 0 | 6 | 7 | 4.79 | .279 | 1.15 | 7.5 | 2.8 | 8.4 | 62.0 | 52 | 33 | 33 | 4 | 19 | 58 | 0 | 39 | 4 | 0 | 0 | 1 | 2 | 2.94 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 7 | 0 | 2 | 0 | 3.66 | .333 | 1.47 | 8.5 | 4.8 | 4.6 | 39.1 | 37 | 17 | 16 | 4 | 21 | 20 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5.00 |