| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 25 | 25 | 10 | 7 | 4.76 | .316 | 1.37 | 9.4 | 3.0 | 8.0 | 155.0 | 162 | 85 | 82 | 19 | 51 | 138 | 1 | 0 | 0 | 0 | 12 | 2 | 4 | 3.84 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 25 | 25 | 9 | 9 | 4.35 | .317 | 1.38 | 7.7 | 4.8 | 4.8 | 144.2 | 123 | 75 | 70 | 8 | 77 | 77 | 0 | 0 | 0 | 0 | 10 | 1 | 1 | 4.28 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 27 | 24 | 6 | 13 | 5.89 | .354 | 1.63 | 10.2 | 4.5 | 5.5 | 139.0 | 158 | 95 | 91 | 23 | 69 | 85 | 2 | 1 | 0 | 0 | 9 | 2 | 2 | 5.46 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 73 | 0 | 3 | 3 | 3.70 | .301 | 1.28 | 9.3 | 2.3 | 7.5 | 97.1 | 100 | 42 | 40 | 8 | 25 | 81 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.21 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 64 | 0 | 6 | 2 | 3.01 | .311 | 1.34 | 7.5 | 4.6 | 8.5 | 74.2 | 62 | 27 | 25 | 1 | 38 | 70 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.86 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 53 | 0 | 6 | 2 | 3.36 | .283 | 1.18 | 7.9 | 2.8 | 6.9 | 64.1 | 56 | 25 | 24 | 6 | 20 | 49 | 0 | 4 | 0 | 0 | 0 | 0 | 4 | 3.63 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 50 | 0 | 1 | 3 | 5.26 | .343 | 1.55 | 9.3 | 4.6 | 10.2 | 53.0 | 55 | 37 | 31 | 7 | 27 | 60 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.04 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 64 | 0 | 2 | 2 | 3.42 | .299 | 1.25 | 5.2 | 6.1 | 9.9 | 71.0 | 41 | 28 | 27 | 5 | 48 | 78 | 0 | 28 | 3 | 0 | 0 | 2 | 1 | 3.83 |