| SP | Mathewson, C.Mathewson, Christy † $ >> | 28 | 1908 | R | 83 | 35 | 35 | 19 | 10 | 2.95 | .273 | 1.10 | 8.1 | 1.8 | 4.4 | 262.2 | 237 | 94 | 86 | 16 | 51 | 128 | 8 | 0 | 0 | 3 | 25 | 8 | 4 | 3.49 |
| SP | Snell, B.Snell, Blake $ >> | 25 | 2018 | L | 80 | 34 | 34 | 21 | 6 | 2.85 | .265 | 1.06 | 5.5 | 4.1 | 7.7 | 221.0 | 135 | 75 | 70 | 19 | 100 | 188 | 0 | 0 | 0 | 0 | 27 | 4 | 12 | 3.83 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 32 | 32 | 16 | 11 | 3.33 | .280 | 1.14 | 7.9 | 2.4 | 4.3 | 243.1 | 214 | 99 | 90 | 23 | 64 | 117 | 10 | 0 | 0 | 1 | 21 | 6 | 5 | 4.13 |
| SP | Fernandez, S.Fernandez, Sid $ >> | 23 | 1985 | L | 49 | 31 | 31 | 10 | 13 | 4.52 | .322 | 1.41 | 8.0 | 4.6 | 6.3 | 197.0 | 176 | 105 | 99 | 24 | 101 | 137 | 1 | 0 | 0 | 0 | 13 | 4 | 3 | 4.79 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 30 | 30 | 11 | 13 | 3.82 | .305 | 1.29 | 7.0 | 4.7 | 4.3 | 195.2 | 151 | 91 | 83 | 10 | 101 | 93 | 3 | 0 | 0 | 3 | 16 | 5 | 2 | 4.34 |
| RP | Feliz, N.Feliz, Neftali † >> | 21 | 2009 | R | 97 | 88 | 0 | 5 | 3 | 2.83 | .265 | 1.06 | 6.3 | 3.2 | 7.1 | 121.0 | 85 | 40 | 38 | 12 | 43 | 95 | 0 | 21 | 4 | 0 | 0 | 3 | 0 | 3.86 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 37 | 0 | 4 | 1 | 1.96 | .220 | 0.83 | 5.1 | 2.3 | 8.4 | 46.0 | 26 | 10 | 10 | 4 | 12 | 43 | 0 | 10 | 1 | 0 | 0 | 1 | 0 | 3.11 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 23 | 0 | 2 | 1 | 3.00 | .283 | 1.19 | 8.0 | 2.7 | 10.7 | 27.0 | 24 | 9 | 9 | 4 | 8 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.44 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 26 | 0 | 2 | 3 | 4.40 | .313 | 1.37 | 8.1 | 4.5 | 7.5 | 30.2 | 27 | 15 | 15 | 3 | 15 | 25 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 4.13 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 21 | 2 | 4 | 4 | 4.93 | .306 | 1.30 | 8.8 | 3.0 | 4.7 | 91.1 | 89 | 50 | 50 | 14 | 30 | 48 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 5.00 |