| SP | Arrieta, J.Arrieta, Jake † # >> | 29 | 2015 | R | 92 | 22 | 22 | 12 | 9 | 3.20 | .283 | 1.17 | 8.2 | 2.4 | 7.5 | 157.2 | 143 | 66 | 56 | 11 | 42 | 131 | 4 | 0 | 0 | 2 | 15 | 2 | 2 | 3.08 |
| SP | Richard, J.Richard, J.R. † >> | 30 | 1980 | R | 90 | 21 | 21 | 12 | 2 | 3.01 | .277 | 1.12 | 6.3 | 3.8 | 8.2 | 140.1 | 98 | 50 | 47 | 8 | 59 | 127 | 1 | 0 | 0 | 1 | 15 | 4 | 4 | 3.28 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 20 | 20 | 8 | 7 | 3.05 | .271 | 1.10 | 7.4 | 2.5 | 5.8 | 147.2 | 121 | 58 | 50 | 9 | 41 | 95 | 3 | 0 | 0 | 0 | 16 | 3 | 0 | 3.40 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 61 | 0 | 3 | 3 | 4.01 | .286 | 1.17 | 6.3 | 4.4 | 9.0 | 60.2 | 42 | 27 | 27 | 6 | 29 | 60 | 0 | 3 | 4 | 0 | 0 | 2 | 0 | 3.85 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 55 | 0 | 3 | 3 | 4.46 | .342 | 1.51 | 7.9 | 5.8 | 9.9 | 42.1 | 37 | 24 | 21 | 7 | 27 | 46 | 0 | 6 | 3 | 0 | 0 | 2 | 2 | 5.05 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 37 | 0 | 3 | 2 | 2.70 | .245 | 0.90 | 5.2 | 3.1 | 7.6 | 26.2 | 15 | 9 | 8 | 4 | 9 | 22 | 0 | 1 | 1 | 0 | 0 | 2 | 3 | 4.58 |
| RP | Hernandez, W.Hernandez, Willie >> | 30 | 1984 | L | 44 | 16 | 0 | 0 | 1 | 2.70 | .231 | 0.90 | 7.5 | 1.5 | 4.5 | 6.2 | 5 | 2 | 2 | 0 | 1 | 3 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.50 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 20 | 0 | 2 | 0 | 4.00 | .413 | 2.11 | 9.0 | 10.0 | 7.0 | 9.0 | 9 | 4 | 4 | 1 | 10 | 7 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 6.22 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 37 | 17 | 0 | 0 | 0 | 0.56 | .238 | 0.88 | 4.5 | 3.4 | 10.1 | 16.0 | 8 | 1 | 1 | 1 | 6 | 18 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 2.88 |