| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 22 | 22 | 12 | 5 | 3.07 | .275 | 1.12 | 6.8 | 3.3 | 7.5 | 155.1 | 117 | 56 | 53 | 14 | 57 | 129 | 1 | 0 | 0 | 0 | 17 | 3 | 3 | 3.67 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 22 | 22 | 9 | 4 | 3.69 | .279 | 1.15 | 7.5 | 2.9 | 5.9 | 141.1 | 117 | 62 | 58 | 19 | 45 | 92 | 0 | 0 | 0 | 0 | 14 | 2 | 1 | 4.45 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 21 | 21 | 6 | 9 | 6.00 | .360 | 1.63 | 9.8 | 4.9 | 8.7 | 108.0 | 117 | 76 | 72 | 9 | 59 | 104 | 0 | 0 | 0 | 0 | 6 | 6 | 1 | 3.96 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 21 | 21 | 13 | 5 | 3.76 | .284 | 1.17 | 8.0 | 2.6 | 4.5 | 136.1 | 121 | 59 | 57 | 16 | 39 | 68 | 0 | 0 | 0 | 0 | 12 | 2 | 0 | 4.43 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 21 | 21 | 6 | 4 | 4.50 | .319 | 1.39 | 9.4 | 3.1 | 4.8 | 152.0 | 158 | 77 | 76 | 21 | 53 | 81 | 3 | 0 | 0 | 1 | 10 | 3 | 2 | 4.84 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 53 | 0 | 2 | 6 | 2.59 | .280 | 1.13 | 8.7 | 1.6 | 7.0 | 55.2 | 53 | 17 | 16 | 1 | 10 | 43 | 0 | 30 | 3 | 0 | 0 | 2 | 0 | 2.33 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 65 | 0 | 7 | 1 | 2.58 | .264 | 1.08 | 7.9 | 1.8 | 7.8 | 59.1 | 52 | 18 | 17 | 6 | 12 | 51 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 3.20 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 43 | 0 | 5 | 2 | 4.62 | .316 | 1.38 | 7.8 | 4.6 | 7.4 | 39.0 | 34 | 23 | 20 | 6 | 20 | 32 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 4.90 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 49 | 0 | 1 | 0 | 1.75 | .234 | 0.92 | 5.5 | 2.8 | 7.5 | 36.0 | 22 | 8 | 7 | 2 | 11 | 30 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 2.97 |
| RP | Treinen, B.Treinen, Blake # >> | 30 | 2018 | R | 80 | 34 | 0 | 4 | 3 | 6.12 | .362 | 1.67 | 10.4 | 4.8 | 9.3 | 32.1 | 37 | 24 | 22 | 8 | 17 | 33 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 5.88 |