| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 22 | 22 | 8 | 9 | 3.94 | .279 | 1.15 | 8.6 | 1.8 | 9.5 | 134.2 | 128 | 62 | 59 | 20 | 27 | 142 | 0 | 0 | 0 | 0 | 13 | 1 | 0 | 3.45 |
| SP | Johnson, W.Johnson, Walter # >> | 26 | 1913 | R | 95 | 22 | 22 | 8 | 9 | 4.76 | .291 | 1.20 | 8.9 | 1.8 | 6.1 | 153.0 | 152 | 90 | 81 | 18 | 31 | 104 | 4 | 0 | 0 | 0 | 10 | 5 | 2 | 3.88 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 21 | 21 | 5 | 11 | 7.45 | .367 | 1.72 | 11.6 | 3.8 | 7.4 | 110.0 | 142 | 99 | 91 | 29 | 47 | 91 | 1 | 0 | 0 | 1 | 6 | 2 | 2 | 6.11 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 21 | 21 | 6 | 6 | 4.50 | .315 | 1.34 | 9.4 | 2.6 | 5.7 | 136.0 | 142 | 72 | 68 | 14 | 40 | 86 | 2 | 0 | 0 | 1 | 13 | 6 | 0 | 4.09 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 20 | 20 | 4 | 8 | 4.70 | .318 | 1.37 | 9.1 | 3.3 | 4.8 | 132.0 | 133 | 73 | 69 | 21 | 48 | 71 | 1 | 0 | 0 | 0 | 9 | 4 | 5 | 5.17 |
| CL | Nathan, J.Nathan, Joe † >> | 32 | 2006 | R | 86 | 51 | 0 | 6 | 8 | 4.64 | .317 | 1.39 | 8.7 | 4.0 | 8.5 | 52.1 | 50 | 28 | 27 | 13 | 23 | 49 | 0 | 19 | 4 | 0 | 0 | 0 | 5 | 5.69 |
| SU | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 51 | 0 | 2 | 3 | 5.87 | .359 | 1.68 | 10.5 | 4.8 | 9.8 | 53.2 | 62 | 37 | 35 | 10 | 28 | 58 | 0 | 0 | 7 | 0 | 0 | 0 | 3 | 4.85 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 55 | 0 | 4 | 1 | 4.85 | .339 | 1.52 | 10.0 | 3.7 | 9.7 | 65.0 | 72 | 38 | 35 | 10 | 27 | 70 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.14 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 46 | 0 | 2 | 2 | 4.55 | .287 | 1.17 | 8.9 | 1.8 | 8.7 | 61.1 | 60 | 31 | 31 | 13 | 12 | 59 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.52 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 37 | 0 | 1 | 3 | 3.80 | .286 | 1.20 | 7.6 | 3.2 | 7.0 | 45.0 | 38 | 20 | 19 | 4 | 16 | 35 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 3.67 |