| SP | Walsh, E.Walsh, Ed † $ >> | 29 | 1910 | R | 93 | 21 | 21 | 10 | 7 | 2.49 | .264 | 1.06 | 7.2 | 2.3 | 5.0 | 170.0 | 136 | 51 | 47 | 13 | 44 | 95 | 8 | 0 | 0 | 2 | 16 | 3 | 2 | 3.71 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 20 | 20 | 8 | 7 | 4.65 | .308 | 1.29 | 8.6 | 3.0 | 5.8 | 137.1 | 131 | 72 | 71 | 17 | 46 | 88 | 2 | 0 | 0 | 1 | 9 | 6 | 4 | 4.47 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 20 | 20 | 10 | 3 | 3.18 | .271 | 1.08 | 7.6 | 2.1 | 7.4 | 130.0 | 110 | 48 | 46 | 11 | 31 | 107 | 0 | 0 | 0 | 0 | 15 | 4 | 4 | 3.26 |
| SP | Ryan, N.Ryan, Nolan # $$ >> | 44 | 1991 | R | 73 | 19 | 19 | 9 | 8 | 3.89 | .275 | 1.12 | 6.3 | 3.8 | 7.2 | 132.0 | 92 | 58 | 57 | 15 | 56 | 105 | 2 | 0 | 0 | 0 | 10 | 2 | 3 | 4.20 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 19 | 19 | 8 | 7 | 3.72 | .297 | 1.24 | 7.2 | 4.0 | 7.7 | 125.2 | 100 | 56 | 52 | 15 | 56 | 107 | 0 | 0 | 0 | 0 | 10 | 3 | 0 | 4.26 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 9 | 0 | 0 | 1 | 3.86 | .364 | 1.71 | 13.0 | 3.0 | 12.0 | 9.1 | 13 | 4 | 4 | 0 | 3 | 12 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1.33 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 27 | 0 | 1 | 2 | 3.33 | .291 | 1.23 | 5.3 | 6.0 | 7.9 | 24.1 | 14 | 9 | 9 | 5 | 16 | 21 | 0 | 2 | 2 | 0 | 0 | 0 | 3 | 5.96 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 49 | 10 | 0 | 2 | 1 | 2.77 | .316 | 1.38 | 7.6 | 4.8 | 8.3 | 13.0 | 11 | 4 | 4 | 1 | 7 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.77 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 8 | 0 | 1 | 0 | 1.46 | .245 | 0.97 | 4.5 | 4.5 | 4.5 | 12.1 | 6 | 3 | 2 | 0 | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.50 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 41 | 3 | 0 | 1 | 0 | 2.60 | .268 | 1.10 | 6.9 | 3.2 | 9.0 | 17.1 | 13 | 5 | 5 | 1 | 6 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.82 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 46 | 0 | 5 | 3 | 1.47 | .203 | 0.75 | 3.9 | 2.8 | 9.7 | 55.0 | 24 | 9 | 9 | 4 | 17 | 59 | 0 | 21 | 1 | 0 | 0 | 1 | 0 | 2.78 |