| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 21 | 21 | 5 | 9 | 4.32 | .299 | 1.26 | 8.7 | 2.7 | 8.7 | 135.1 | 131 | 65 | 65 | 16 | 40 | 130 | 0 | 0 | 0 | 0 | 14 | 2 | 0 | 3.55 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 20 | 20 | 4 | 9 | 5.90 | .330 | 1.44 | 9.3 | 3.8 | 8.5 | 108.1 | 111 | 76 | 71 | 20 | 45 | 102 | 0 | 0 | 0 | 0 | 10 | 4 | 1 | 4.88 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 20 | 20 | 7 | 7 | 4.38 | .313 | 1.35 | 9.0 | 3.1 | 4.3 | 109.0 | 109 | 59 | 53 | 10 | 38 | 52 | 0 | 0 | 0 | 0 | 8 | 2 | 2 | 4.34 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 20 | 20 | 5 | 6 | 5.62 | .332 | 1.47 | 10.1 | 3.2 | 4.7 | 131.1 | 147 | 83 | 82 | 18 | 46 | 69 | 2 | 0 | 0 | 0 | 6 | 3 | 2 | 4.85 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 20 | 19 | 3 | 12 | 5.92 | .335 | 1.50 | 9.8 | 3.6 | 5.4 | 117.0 | 128 | 79 | 77 | 14 | 47 | 70 | 4 | 1 | 0 | 0 | 6 | 2 | 3 | 4.62 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 37 | 0 | 0 | 3 | 1.80 | .250 | 1.00 | 6.1 | 2.9 | 11.9 | 40.0 | 27 | 8 | 8 | 2 | 13 | 53 | 0 | 17 | 2 | 0 | 0 | 0 | 1 | 1.98 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 51 | 0 | 4 | 1 | 2.63 | .297 | 1.25 | 8.0 | 3.4 | 9.3 | 61.2 | 54 | 18 | 18 | 5 | 23 | 63 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.18 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 48 | 0 | 7 | 2 | 3.68 | .339 | 1.50 | 8.1 | 5.5 | 11.3 | 51.1 | 46 | 23 | 21 | 3 | 31 | 64 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 3.20 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 20 | 0 | 3 | 4 | 5.23 | .340 | 1.47 | 9.6 | 3.6 | 8.1 | 62.0 | 66 | 36 | 36 | 10 | 25 | 56 | 0 | 1 | 0 | 0 | 0 | 5 | 3 | 4.74 |