| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 32 | 32 | 11 | 11 | 4.69 | .332 | 1.47 | 9.9 | 3.3 | 6.4 | 213.0 | 235 | 122 | 111 | 34 | 78 | 152 | 4 | 0 | 0 | 0 | 14 | 4 | 6 | 4.80 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 32 | 32 | 6 | 23 | 5.38 | .323 | 1.40 | 9.7 | 2.9 | 4.8 | 219.0 | 236 | 138 | 131 | 31 | 70 | 116 | 13 | 0 | 0 | 1 | 12 | 7 | 11 | 4.84 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 52 | 32 | 31 | 9 | 9 | 7.07 | .353 | 1.61 | 10.5 | 4.0 | 5.5 | 163.0 | 190 | 132 | 128 | 32 | 73 | 99 | 0 | 0 | 0 | 0 | 10 | 4 | 2 | 5.75 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 91 | 0 | 10 | 4 | 3.34 | .284 | 1.18 | 6.9 | 3.7 | 7.3 | 118.2 | 91 | 45 | 44 | 11 | 49 | 96 | 0 | 7 | 5 | 0 | 0 | 1 | 2 | 3.86 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 77 | 0 | 3 | 7 | 2.26 | .265 | 1.04 | 7.1 | 2.4 | 7.2 | 103.2 | 81 | 32 | 26 | 11 | 27 | 82 | 0 | 10 | 3 | 0 | 0 | 4 | 1 | 3.70 |
| RP | Dotel, O.Dotel, Octavio # >> | 29 | 2002 | R | 69 | 55 | 0 | 6 | 5 | 4.81 | .327 | 1.44 | 9.3 | 3.8 | 9.7 | 67.1 | 69 | 38 | 36 | 11 | 28 | 72 | 0 | 4 | 3 | 0 | 0 | 1 | 0 | 4.28 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 54 | 37 | 0 | 1 | 2 | 4.26 | .310 | 1.32 | 8.5 | 3.3 | 8.4 | 57.0 | 54 | 29 | 27 | 7 | 21 | 53 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 3.95 |