| SP | Verlander, J.Verlander, Justin # >> | 36 | 2019 | R | 99 | 34 | 34 | 7 | 17 | 5.74 | .323 | 1.41 | 9.5 | 3.2 | 8.3 | 213.1 | 225 | 138 | 136 | 34 | 75 | 196 | 2 | 0 | 0 | 1 | 16 | 5 | 4 | 4.36 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 33 | 33 | 11 | 18 | 4.53 | .320 | 1.38 | 9.4 | 3.1 | 4.2 | 236.2 | 246 | 132 | 119 | 27 | 80 | 110 | 7 | 0 | 0 | 1 | 15 | 8 | 5 | 4.67 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 32 | 32 | 7 | 22 | 5.04 | .317 | 1.36 | 9.1 | 3.1 | 5.3 | 244.2 | 248 | 148 | 137 | 34 | 84 | 144 | 9 | 0 | 0 | 0 | 14 | 9 | 5 | 4.77 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 32 | 32 | 9 | 17 | 4.56 | .320 | 1.39 | 9.3 | 3.2 | 4.1 | 245.0 | 254 | 137 | 124 | 30 | 87 | 112 | 13 | 0 | 0 | 1 | 15 | 5 | 4 | 4.80 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 31 | 31 | 10 | 19 | 5.22 | .344 | 1.55 | 10.0 | 4.0 | 4.3 | 205.1 | 228 | 127 | 119 | 20 | 90 | 99 | 4 | 0 | 0 | 1 | 13 | 5 | 4 | 4.69 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 78 | 0 | 10 | 1 | 3.32 | .250 | 0.97 | 6.7 | 2.0 | 8.9 | 103.0 | 77 | 38 | 38 | 12 | 23 | 102 | 0 | 6 | 1 | 0 | 0 | 3 | 1 | 3.29 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 39 | 0 | 2 | 4 | 7.34 | .384 | 1.84 | 9.9 | 6.6 | 9.7 | 38.0 | 42 | 31 | 31 | 4 | 28 | 41 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 4.50 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 35 | 0 | 1 | 0 | 2.47 | .238 | 0.94 | 4.0 | 4.6 | 9.6 | 43.2 | 19 | 12 | 12 | 3 | 22 | 46 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.30 |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 3 | 0 | 0 | 0 | 5.68 | .367 | 1.74 | 13.5 | 3.0 | 7.5 | 6.1 | 9 | 4 | 4 | 1 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 17 | 0 | 0 | 4 | 5.67 | .382 | 1.81 | 10.0 | 6.3 | 7.0 | 27.0 | 30 | 17 | 17 | 3 | 19 | 21 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 5.11 |