| SP | Schilling, C.Schilling, Curt † >> | 36 | 2002 | R | 93 | 19 | 19 | 11 | 7 | 3.26 | .301 | 1.28 | 9.9 | 1.6 | 9.7 | 143.2 | 158 | 59 | 52 | 14 | 26 | 154 | 7 | 0 | 0 | 3 | 12 | 2 | 1 | 2.71 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 18 | 18 | 3 | 6 | 6.18 | .352 | 1.60 | 10.4 | 4.0 | 6.2 | 83.0 | 96 | 58 | 57 | 12 | 37 | 57 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.92 |
| SP | Garcia, F.Garcia, Freddy # >> | 26 | 2001 | R | 61 | 18 | 18 | 5 | 9 | 5.06 | .324 | 1.39 | 9.8 | 2.7 | 5.7 | 117.1 | 128 | 67 | 66 | 25 | 35 | 74 | 2 | 0 | 0 | 2 | 7 | 6 | 2 | 5.56 |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 47 | 17 | 17 | 5 | 6 | 5.35 | .336 | 1.50 | 9.8 | 3.7 | 6.6 | 99.1 | 108 | 59 | 59 | 16 | 41 | 73 | 0 | 0 | 0 | 0 | 8 | 2 | 4 | 4.93 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 47 | 0 | 3 | 5 | 3.12 | .276 | 1.12 | 7.8 | 2.3 | 9.0 | 66.1 | 57 | 25 | 23 | 8 | 17 | 66 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 3.44 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 60 | 41 | 0 | 5 | 1 | 4.31 | .259 | 1.05 | 6.6 | 2.9 | 10.4 | 56.1 | 41 | 27 | 27 | 8 | 18 | 65 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 3.50 |
| RP | Linebrink, S.Linebrink, Scott >> | 28 | 2004 | R | 43 | 36 | 0 | 1 | 2 | 7.57 | .365 | 1.70 | 12.1 | 3.3 | 7.4 | 44.0 | 59 | 38 | 37 | 14 | 16 | 36 | 0 | 6 | 1 | 0 | 0 | 1 | 3 | 6.66 |
| RP | Ziegler, B.Ziegler, Brad + >> | 29 | 2008 | R | 15 | 24 | 0 | 0 | 2 | 3.72 | .293 | 1.24 | 7.4 | 3.7 | 5.9 | 29.0 | 24 | 12 | 12 | 4 | 12 | 19 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.72 |
| SP | Volquez, E.Volquez, Edinson >> | 25 | 2008 | R | 26 | 14 | 0 | 3 | 4 | 2.70 | .333 | 1.46 | 7.4 | 5.9 | 7.0 | 23.1 | 19 | 7 | 7 | 2 | 15 | 18 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 4.65 |