| SP | Arrieta, J.Arrieta, Jake $ >> | 29 | 2015 | R | 95 | 32 | 32 | 13 | 16 | 5.05 | .317 | 1.35 | 9.6 | 2.6 | 8.3 | 213.2 | 227 | 123 | 120 | 28 | 61 | 197 | 2 | 0 | 0 | 0 | 13 | 9 | 4 | 3.85 |
| SP | Johnson, R.Johnson, Randy $ >> | 41 | 2004 | L | 90 | 31 | 31 | 14 | 9 | 3.43 | .283 | 1.17 | 8.0 | 2.5 | 9.0 | 225.2 | 200 | 88 | 86 | 30 | 63 | 224 | 4 | 0 | 0 | 1 | 19 | 4 | 3 | 3.64 |
| SP | Hunter, C.Hunter, Catfish † # >> | 26 | 1972 | R | 84 | 31 | 31 | 22 | 7 | 3.11 | .260 | 1.04 | 6.8 | 2.5 | 5.9 | 252.0 | 191 | 91 | 87 | 37 | 71 | 164 | 17 | 0 | 0 | 4 | 19 | 3 | 7 | 4.49 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 77 | 31 | 31 | 13 | 11 | 4.60 | .326 | 1.43 | 9.4 | 3.4 | 8.8 | 205.1 | 215 | 115 | 105 | 39 | 78 | 201 | 1 | 0 | 0 | 0 | 15 | 5 | 1 | 4.73 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 67 | 29 | 29 | 12 | 8 | 3.51 | .284 | 1.16 | 7.1 | 3.4 | 8.6 | 187.1 | 147 | 76 | 73 | 22 | 70 | 178 | 0 | 0 | 0 | 0 | 16 | 6 | 4 | 3.84 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 96 | 86 | 0 | 7 | 0 | 3.00 | .250 | 0.98 | 6.3 | 2.5 | 10.2 | 111.0 | 78 | 38 | 37 | 14 | 31 | 126 | 0 | 8 | 8 | 0 | 0 | 2 | 3 | 3.26 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 90 | 62 | 0 | 9 | 1 | 3.07 | .280 | 1.16 | 6.5 | 4.0 | 11.1 | 85.0 | 61 | 31 | 29 | 10 | 38 | 105 | 0 | 7 | 3 | 0 | 0 | 0 | 0 | 3.40 |
| RP | Capps, C.Capps, Carter $ >> | 24 | 2015 | R | 83 | 39 | 0 | 3 | 3 | 2.86 | .286 | 1.14 | 6.3 | 3.9 | 9.4 | 44.0 | 31 | 14 | 14 | 2 | 19 | 46 | 0 | 8 | 1 | 0 | 0 | 3 | 2 | 3.00 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 26 | 0 | 2 | 2 | 8.00 | .347 | 1.52 | 11.3 | 2.3 | 10.7 | 27.0 | 34 | 24 | 24 | 9 | 7 | 32 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 5.96 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 77 | 35 | 0 | 1 | 1 | 3.95 | .301 | 1.24 | 8.8 | 2.4 | 7.0 | 41.0 | 40 | 18 | 18 | 7 | 11 | 32 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.61 |