| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 17 | 17 | 7 | 5 | 3.58 | .275 | 1.11 | 6.5 | 3.5 | 8.1 | 118.0 | 85 | 48 | 47 | 14 | 46 | 106 | 2 | 0 | 0 | 1 | 10 | 3 | 0 | 3.99 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 87 | 16 | 16 | 6 | 8 | 6.45 | .366 | 1.70 | 10.6 | 4.8 | 9.5 | 90.2 | 106 | 65 | 65 | 18 | 48 | 95 | 0 | 0 | 0 | 0 | 7 | 3 | 3 | 5.19 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 89 | 16 | 16 | 9 | 3 | 3.59 | .293 | 1.23 | 8.1 | 3.0 | 9.6 | 107.2 | 96 | 45 | 43 | 10 | 36 | 114 | 1 | 0 | 0 | 1 | 10 | 2 | 1 | 3.15 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 72 | 16 | 16 | 7 | 5 | 5.42 | .336 | 1.44 | 10.1 | 2.9 | 6.7 | 108.0 | 121 | 66 | 65 | 19 | 35 | 80 | 2 | 0 | 0 | 0 | 5 | 8 | 1 | 5.00 |
| RP | Doolittle, S.Doolittle, Sean † $ >> | 31 | 2018 | L | 98 | 53 | 0 | 5 | 2 | 2.26 | .201 | 0.71 | 4.7 | 1.7 | 10.7 | 67.2 | 35 | 18 | 17 | 7 | 13 | 80 | 0 | 4 | 2 | 0 | 0 | 3 | 3 | 2.69 |
| RP | Chapman, A.Chapman, Aroldis $ >> | 37 | 2025 | L | 96 | 40 | 0 | 2 | 1 | 3.80 | .260 | 1.06 | 5.6 | 4.0 | 10.1 | 47.1 | 29 | 20 | 20 | 8 | 21 | 53 | 0 | 6 | 2 | 0 | 0 | 0 | 2 | 4.30 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 28 | 0 | 0 | 2 | 4.59 | .310 | 1.35 | 9.8 | 2.5 | 11.2 | 33.1 | 36 | 17 | 17 | 11 | 9 | 41 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 5.67 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 83 | 23 | 0 | 2 | 0 | 2.45 | .248 | 0.95 | 7.1 | 1.6 | 11.8 | 29.1 | 23 | 11 | 8 | 3 | 5 | 38 | 0 | 2 | 0 | 0 | 0 | 1 | 3 | 2.34 |