| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 17 | 17 | 10 | 2 | 1.89 | .232 | 0.91 | 6.1 | 2.1 | 9.8 | 123.2 | 83 | 28 | 26 | 15 | 29 | 134 | 1 | 0 | 0 | 1 | 14 | 0 | 0 | 3.11 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 78 | 16 | 16 | 6 | 7 | 4.87 | .315 | 1.35 | 9.2 | 3.1 | 6.6 | 114.2 | 116 | 62 | 62 | 18 | 39 | 84 | 6 | 0 | 0 | 0 | 7 | 3 | 4 | 4.68 |
| SP | Hamels, C.Hamels, Cole >> | 28 | 2011 | L | 62 | 16 | 16 | 5 | 9 | 6.11 | .337 | 1.49 | 10.3 | 3.1 | 6.9 | 101.2 | 116 | 69 | 69 | 19 | 35 | 77 | 1 | 0 | 0 | 0 | 7 | 4 | 1 | 5.08 |
| SP | Valenzuela, F.Valenzuela, Fernando >> | 21 | 1981 | L | 60 | 16 | 16 | 6 | 10 | 5.08 | .316 | 1.37 | 8.8 | 3.6 | 6.1 | 108.0 | 105 | 66 | 61 | 16 | 43 | 73 | 3 | 0 | 0 | 1 | 6 | 2 | 1 | 4.82 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 73 | 39 | 0 | 3 | 1 | 3.67 | .298 | 1.27 | 7.7 | 4.0 | 9.2 | 41.2 | 35 | 18 | 17 | 3 | 18 | 42 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 3.22 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 65 | 24 | 0 | 1 | 0 | 2.25 | .250 | 0.96 | 5.3 | 3.4 | 10.1 | 24.0 | 14 | 7 | 6 | 2 | 9 | 27 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 3.08 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 57 | 14 | 0 | 0 | 1 | 2.45 | .290 | 1.16 | 7.1 | 3.9 | 4.5 | 14.2 | 11 | 7 | 4 | 0 | 6 | 7 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.50 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 56 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Candelaria, J.Candelaria, John >> | 33 | 1986 | L | 54 | 1 | 0 | 0 | 0 | 0.00 | .167 | 0.60 | 0.0 | 9.0 | 0.0 | 1.2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.00 |