| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 33 | 33 | 22 | 5 | 2.78 | .262 | 1.06 | 6.9 | 2.6 | 10.4 | 217.0 | 167 | 73 | 67 | 25 | 62 | 250 | 1 | 0 | 0 | 1 | 23 | 2 | 0 | 3.08 |
| SP | Santana, J.Santana, Johan † # >> | 25 | 2004 | L | 91 | 32 | 32 | 10 | 10 | 3.99 | .309 | 1.32 | 8.0 | 4.0 | 9.3 | 209.2 | 185 | 101 | 93 | 31 | 92 | 216 | 2 | 0 | 0 | 2 | 20 | 4 | 5 | 4.24 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 30 | 30 | 15 | 8 | 3.18 | .275 | 1.13 | 8.0 | 2.2 | 6.2 | 215.1 | 191 | 84 | 76 | 23 | 52 | 147 | 3 | 0 | 0 | 2 | 22 | 2 | 3 | 3.78 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 77 | 30 | 30 | 12 | 12 | 5.32 | .343 | 1.53 | 9.6 | 4.1 | 5.8 | 176.0 | 188 | 110 | 104 | 34 | 81 | 114 | 1 | 0 | 0 | 0 | 15 | 7 | 5 | 5.72 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 78 | 76 | 0 | 5 | 9 | 3.38 | .320 | 1.36 | 7.3 | 5.0 | 9.2 | 80.0 | 65 | 30 | 30 | 11 | 44 | 82 | 0 | 3 | 1 | 0 | 0 | 4 | 0 | 4.54 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 76 | 55 | 0 | 3 | 1 | 3.23 | .306 | 1.30 | 8.0 | 3.7 | 8.8 | 53.0 | 47 | 19 | 19 | 9 | 22 | 52 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 4.55 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 68 | 31 | 0 | 0 | 1 | 4.31 | .293 | 1.24 | 5.2 | 6.1 | 10.2 | 31.1 | 18 | 15 | 15 | 3 | 21 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.03 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 52 | 0 | 4 | 6 | 2.61 | .241 | 0.92 | 5.0 | 3.4 | 11.6 | 58.2 | 32 | 19 | 17 | 6 | 22 | 75 | 0 | 35 | 4 | 0 | 0 | 2 | 2 | 3.00 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 65 | 14 | 1 | 2 | 1 | 4.16 | .327 | 1.42 | 9.0 | 3.8 | 10.3 | 71.1 | 71 | 36 | 33 | 10 | 30 | 81 | 0 | 0 | 0 | 0 | 1 | 3 | 3 | 3.94 |