| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 38 | 38 | 14 | 14 | 4.51 | .298 | 1.26 | 8.1 | 3.3 | 6.2 | 235.2 | 211 | 126 | 118 | 45 | 86 | 162 | 6 | 0 | 0 | 0 | 19 | 3 | 3 | 5.25 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 37 | 37 | 24 | 7 | 2.58 | .276 | 1.13 | 6.6 | 3.5 | 5.3 | 251.1 | 184 | 75 | 72 | 20 | 99 | 147 | 0 | 0 | 0 | 0 | 30 | 4 | 4 | 4.10 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 35 | 35 | 13 | 10 | 4.01 | .302 | 1.29 | 8.0 | 3.6 | 7.3 | 215.2 | 192 | 103 | 96 | 18 | 86 | 174 | 1 | 0 | 0 | 0 | 19 | 2 | 2 | 3.70 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 35 | 35 | 15 | 11 | 4.09 | .291 | 1.23 | 6.8 | 4.2 | 4.7 | 220.0 | 167 | 105 | 100 | 25 | 103 | 116 | 2 | 0 | 0 | 1 | 18 | 1 | 1 | 4.84 |
| RP | Chapman, A.Chapman, Aroldis >> | 37 | 2025 | L | 96 | 103 | 0 | 6 | 2 | 2.27 | .264 | 1.07 | 5.7 | 3.9 | 8.8 | 135.0 | 86 | 37 | 34 | 11 | 59 | 132 | 0 | 11 | 2 | 0 | 0 | 0 | 8 | 3.41 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 95 | 0 | 7 | 5 | 3.34 | .273 | 1.08 | 5.6 | 4.2 | 7.3 | 107.2 | 66 | 40 | 40 | 11 | 50 | 87 | 0 | 6 | 2 | 0 | 0 | 5 | 0 | 4.25 |
| RP | Clippard, T.Clippard, Tyler # >> | 26 | 2011 | R | 79 | 72 | 0 | 6 | 3 | 5.11 | .325 | 1.42 | 8.6 | 4.2 | 7.6 | 81.0 | 77 | 48 | 46 | 18 | 38 | 68 | 0 | 14 | 1 | 0 | 0 | 2 | 1 | 5.69 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 56 | 0 | 5 | 6 | 5.13 | .301 | 1.28 | 8.4 | 3.1 | 7.3 | 72.0 | 67 | 46 | 41 | 12 | 25 | 58 | 0 | 8 | 6 | 0 | 0 | 1 | 0 | 4.64 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 43 | 0 | 2 | 1 | 3.40 | .278 | 1.13 | 6.3 | 4.0 | 9.4 | 50.1 | 35 | 19 | 19 | 7 | 22 | 52 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 4.12 |