| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 21 | 21 | 6 | 9 | 3.84 | .275 | 1.13 | 7.4 | 2.7 | 7.8 | 150.0 | 124 | 64 | 64 | 19 | 45 | 130 | 8 | 0 | 0 | 2 | 13 | 2 | 3 | 3.85 |
| SP | Santana, J.Santana, Johan $ >> | 25 | 2004 | L | 86 | 20 | 20 | 6 | 10 | 5.21 | .330 | 1.46 | 9.4 | 3.8 | 8.5 | 122.2 | 127 | 72 | 71 | 14 | 52 | 115 | 0 | 0 | 0 | 0 | 10 | 2 | 3 | 3.93 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 19 | 19 | 8 | 7 | 4.51 | .307 | 1.32 | 9.5 | 2.4 | 5.2 | 127.2 | 134 | 64 | 64 | 17 | 34 | 73 | 0 | 0 | 0 | 0 | 10 | 2 | 1 | 4.44 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 42 | 0 | 3 | 9 | 4.91 | .309 | 1.32 | 8.6 | 3.4 | 9.0 | 47.2 | 45 | 27 | 26 | 6 | 18 | 47 | 0 | 20 | 4 | 0 | 0 | 1 | 0 | 3.87 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 48 | 0 | 4 | 2 | 2.89 | .272 | 1.09 | 6.5 | 3.3 | 8.7 | 62.1 | 45 | 20 | 20 | 4 | 23 | 60 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 3.11 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 43 | 0 | 2 | 2 | 2.87 | .273 | 1.09 | 5.4 | 4.4 | 5.6 | 47.0 | 28 | 17 | 15 | 3 | 23 | 29 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 4.19 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 17 | 0 | 0 | 1 | 3.27 | .258 | 1.00 | 7.8 | 1.2 | 9.0 | 22.0 | 19 | 8 | 8 | 5 | 3 | 22 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.50 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 13 | 0 | 0 | 0 | 4.41 | .338 | 1.53 | 10.7 | 3.4 | 7.9 | 16.1 | 19 | 8 | 8 | 1 | 6 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.19 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 3 | 1 | 0 | 3 | 3.21 | .300 | 1.29 | 5.8 | 5.8 | 8.4 | 14.0 | 9 | 5 | 5 | 1 | 9 | 13 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.00 |