| SP | Tiant, L.Tiant, Luis † >> | 28 | 1968 | R | 97 | 34 | 34 | 18 | 12 | 3.15 | .285 | 1.19 | 7.0 | 3.7 | 7.5 | 260.1 | 203 | 102 | 91 | 21 | 106 | 217 | 11 | 0 | 0 | 3 | 25 | 2 | 0 | 3.63 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 32 | 32 | 15 | 8 | 4.37 | .292 | 1.22 | 8.1 | 2.9 | 7.4 | 224.1 | 201 | 120 | 109 | 28 | 73 | 185 | 5 | 0 | 0 | 2 | 14 | 3 | 2 | 3.99 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 32 | 32 | 12 | 14 | 6.21 | .351 | 1.61 | 11.0 | 3.5 | 4.7 | 200.0 | 244 | 146 | 138 | 37 | 77 | 105 | 5 | 0 | 0 | 0 | 10 | 4 | 7 | 5.57 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 63 | 31 | 31 | 7 | 22 | 7.24 | .348 | 1.59 | 11.9 | 2.4 | 5.2 | 179.0 | 236 | 151 | 144 | 31 | 48 | 103 | 3 | 0 | 0 | 1 | 9 | 2 | 5 | 4.94 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 89 | 0 | 4 | 4 | 3.79 | .301 | 1.26 | 8.1 | 3.3 | 8.5 | 116.1 | 104 | 54 | 49 | 17 | 43 | 109 | 0 | 13 | 1 | 0 | 0 | 3 | 5 | 4.22 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 69 | 0 | 7 | 2 | 5.70 | .332 | 1.48 | 8.8 | 4.7 | 9.4 | 83.2 | 81 | 53 | 53 | 13 | 43 | 87 | 0 | 6 | 1 | 0 | 0 | 1 | 1 | 4.53 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 51 | 0 | 0 | 3 | 5.68 | .335 | 1.51 | 8.2 | 5.4 | 9.8 | 57.0 | 52 | 37 | 36 | 3 | 34 | 62 | 0 | 4 | 0 | 0 | 0 | 0 | 4 | 3.30 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 54 | 36 | 0 | 4 | 2 | 2.98 | .317 | 1.39 | 8.6 | 4.0 | 10.4 | 45.1 | 43 | 22 | 15 | 8 | 20 | 52 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.33 |
| SP | Cooper, M.Cooper, Mort >> | 29 | 1942 | R | 47 | 13 | 0 | 0 | 1 | 6.46 | .410 | 2.09 | 15.0 | 4.2 | 4.8 | 15.1 | 25 | 11 | 11 | 3 | 7 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.93 |