| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 36 | 36 | 17 | 17 | 4.73 | .303 | 1.28 | 8.2 | 3.3 | 8.6 | 266.2 | 243 | 148 | 140 | 39 | 99 | 253 | 6 | 0 | 0 | 1 | 16 | 5 | 5 | 4.18 |
| SP | Santana, J.Santana, Johan † # >> | 25 | 2004 | L | 86 | 34 | 34 | 17 | 10 | 4.14 | .290 | 1.20 | 8.3 | 2.5 | 8.2 | 239.1 | 221 | 112 | 110 | 39 | 67 | 217 | 7 | 0 | 0 | 3 | 22 | 5 | 1 | 4.21 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 70 | 33 | 33 | 9 | 17 | 5.46 | .325 | 1.42 | 10.0 | 2.8 | 8.2 | 244.0 | 270 | 163 | 148 | 37 | 77 | 221 | 9 | 0 | 0 | 0 | 13 | 5 | 4 | 4.17 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 33 | 33 | 11 | 18 | 6.32 | .350 | 1.59 | 11.4 | 2.9 | 7.4 | 205.0 | 259 | 150 | 144 | 32 | 67 | 168 | 1 | 0 | 0 | 0 | 11 | 5 | 8 | 4.44 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 91 | 0 | 4 | 5 | 3.87 | .277 | 1.14 | 7.5 | 2.8 | 8.1 | 114.0 | 95 | 49 | 49 | 18 | 35 | 102 | 0 | 12 | 3 | 0 | 0 | 1 | 3 | 4.21 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 58 | 0 | 1 | 2 | 4.63 | .329 | 1.47 | 6.8 | 6.5 | 7.8 | 68.0 | 51 | 36 | 35 | 7 | 49 | 59 | 0 | 6 | 2 | 0 | 0 | 0 | 2 | 4.76 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 0 | 0 | 0 | 18.00 | .438 | 2.33 | 15.0 | 6.0 | 3.0 | 3.0 | 5 | 6 | 6 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 17.33 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 27 | 0 | 3 | 3 | 4.45 | .355 | 1.62 | 11.0 | 3.7 | 4.7 | 58.2 | 71 | 30 | 29 | 5 | 24 | 30 | 0 | 0 | 1 | 0 | 0 | 2 | 2 | 4.43 |