| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 21 | 21 | 3 | 8 | 6.21 | .342 | 1.54 | 11.0 | 2.9 | 8.8 | 137.2 | 168 | 100 | 95 | 30 | 44 | 134 | 1 | 0 | 0 | 0 | 7 | 3 | 2 | 4.92 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 20 | 20 | 11 | 8 | 4.98 | .322 | 1.40 | 9.2 | 3.4 | 7.8 | 119.1 | 122 | 67 | 66 | 15 | 45 | 103 | 1 | 0 | 0 | 1 | 10 | 3 | 2 | 4.12 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 20 | 20 | 8 | 5 | 4.71 | .315 | 1.35 | 9.2 | 3.0 | 5.0 | 114.2 | 117 | 66 | 60 | 17 | 38 | 63 | 1 | 0 | 0 | 1 | 10 | 3 | 4 | 4.91 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 21 | 19 | 10 | 3 | 4.63 | .318 | 1.38 | 9.6 | 2.9 | 7.5 | 124.1 | 132 | 67 | 64 | 14 | 40 | 104 | 4 | 1 | 0 | 0 | 9 | 2 | 4 | 3.81 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 52 | 0 | 3 | 6 | 3.09 | .242 | 0.96 | 7.1 | 1.6 | 7.4 | 58.1 | 46 | 20 | 20 | 7 | 10 | 48 | 0 | 25 | 3 | 0 | 0 | 0 | 0 | 3.43 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 50 | 0 | 1 | 1 | 3.81 | .306 | 1.29 | 6.3 | 5.3 | 8.7 | 54.1 | 38 | 23 | 23 | 10 | 32 | 52 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.37 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 51 | 0 | 5 | 2 | 4.12 | .308 | 1.28 | 8.7 | 3.0 | 12.3 | 54.2 | 52 | 25 | 25 | 9 | 18 | 74 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 3.59 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 33 | 0 | 2 | 2 | 5.44 | .335 | 1.42 | 9.2 | 3.6 | 10.3 | 43.0 | 44 | 26 | 26 | 5 | 17 | 49 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 3.70 |